Abstract Severe chronic hand eczema resistant to topical corticosteroid treatment is an important cause of morbidity and occupational disability. There uncertainty regarding the best approach currently no pathway generally accepted by UK dermatologists. The primary aim ALPHA trial was compare alitretinoin immersion psoralen plus ultraviolet A (PUVA) as a first-line therapy in terms disease acti...

Background: Phototherapy is a safe and effective treatment modality for skin diseases in children such as psoriasis, atopic dermatitis, pityriasis lichenoides, vitiligo, cutaneous cell lymphoma, rubra pilaris, other disorders. It reported to be with less side effects compare the administration of systemic medicine. Short long term should taken into account when applying this model therapy, espe...

Case Report A 53-year-old male anaesthetist with a widespread, histologically proven psoriasis vulgaris was treated with oral photochemotherapy (PUVA) after failure of multiple intensive topical treatments and poor response to UVA-UVB phototherapy. PUVA was begun according to our standard protocol: 2 h after oral administration of 5-MOP 100 mg (Geralen , 1.2 mg/kg body weight), the patient was ...

Case Report A 53-year-old male anaesthetist with a widespread, histologically proven psoriasis vulgaris was treated with oral photochemotherapy (PUVA) after failure of multiple intensive topical treatments and poor response to UVA-UVB phototherapy. PUVA was begun according to our standard protocol: 2 h after oral administration of 5-MOP 100 mg (Geralen , 1.2 mg/kg body weight), the patient was ...

To elucidate the molecular action of 8-methoxypsoralen plus UVA (PUVA), a standard dermatological therapy, we used K5.hTGF-beta1 transgenic mice exhibiting a skin phenotype and cytokine abnormalities with strong similarities to human psoriasis. We observed that impaired function of CD4+CD25+ regulatory T cells (Tregs) and increased cytokine levels of the IL-23/Th17 pathway were responsible for ...

Case Report A 53-year-old male anaesthetist with a widespread, histologically proven psoriasis vulgaris was treated with oral photochemotherapy (PUVA) after failure of multiple intensive topical treatments and poor response to UVA-UVB phototherapy. PUVA was begun according to our standard protocol: 2 h after oral administration of 5-MOP 100 mg (Geralen , 1.2 mg/kg body weight), the patient was ...

Case Report A 53-year-old male anaesthetist with a widespread, histologically proven psoriasis vulgaris was treated with oral photochemotherapy (PUVA) after failure of multiple intensive topical treatments and poor response to UVA-UVB phototherapy. PUVA was begun according to our standard protocol: 2 h after oral administration of 5-MOP 100 mg (Geralen , 1.2 mg/kg body weight), the patient was ...

Background: Palmoplantar eczema is a common clinical problem involving 2% of the population. There are many treatment modalities for palmoplantar eczema, each with specific local and systemic side effects. Objective: To evaluate methoxsalen bath in the treatment of palmoplantar eczema. Patients and Methods: In a randomized, double-blind, placebo controlled clinical trial, 60 patients with palmo...

Antigen Ki-67 is a non-histone nuclear protein, closely connected with cell proliferation. Determining Ki-67 allows for a quick and reliable evaluation of the growth fraction of the studied cell population. It serves as a marker of proliferative activity in neoplasms and other diseases with excessive cell proliferation such as psoriasis. Evaluation of Ki-67 expression in epidermal cells was per...