Epidemiological data on carbapenemase-producing Gram-negative bacteria on the African continent are limited. Here, we report the identification of VIM-2-producing Pseudomonas aeruginosa isolates in Tanzania. Eight out of 90 clinical isolates of P. aeruginosa from a tertiary care hospital in Dar es Salaam were shown to harbor bla(VIM-2). The bla(VIM-2)-positive isolates belonged to two different...

Background: Escherichia coli, a gram-negative bacterium, is the causative agent for approximately 80% of urinary tract infections (UTIs). UTI treatment has resulted in overuse antibiotics hospitals and communities, subsequently increase antimicrobial resistance. The emergence extensively drug resistance (XDR) strains become costly dangerous challenge most bacterial UTIs. Objective: This study a...

Antimicrobial resistance (AR) represents a global threat in human and veterinary medicine. In that regard, AR proliferation dissemination agricultural soils after manure application raises concerns on the enrichment of endogenous soil bacterial population with allochthonous antibiotic genes (ARGs). Natural resilience background concentrations ARGs play key roles mitigation propagation natural e...

Antibiotic resistance genes (ARGs) are emerging environmental contaminants, known to be continuously discharged into the aquatic environment via human and animal waste. Freshwater aquatic environments represent potential reservoirs for ARG and potentially allow sewage-derived ARG to persist and spread in the environment. This may create increased opportunities for an eventual contact with, and ...

Treated wastewater is increasingly being reused to achieve sustainable water management in arid regions. The objective of this study was to quantify the distribution of antibiotic resistance genes (ARGs) in recycled water, particularly after it has passed through the distribution system, and to consider point-of-use implications for soil irrigation. Three separate reclaimed wastewater distribut...

The soil-borne pathogen Nocardia sp. causes severe cutaneous, pulmonary, and central nervous system infections. Against them, co-trimoxazole (SXT) constitutes the mainstay of antimicrobial therapy. However, some Nocardia strains show resistance to SXT, but the underlying genetic basis is unknown. We investigated the presence of genetic resistance determinants and class 1-3 integrons in 76 SXT-r...