objective(s) this investigation was conducted to evaluate the effects of diabetes on the structure and function of testicular tissue. materials and methods diabetes was induced in male adult rats by a single intraperitoneal injection of streptozotocin. body and testicular weight, hormonal analyses, histological and ultrastructural analyses were measured. results the body and testicular weights ...

Basement membrane thickness was measured in two groups of spiny mice (Acomys cahirinus): one with spontaneous diabetes, the other with streptozotocin-induced diabetes. A statistical analysis of the morphometric results of the two groups showed a significant basement membrane thickening in the group with induced diabetes when compared to the spontaneously diabetic group.

Objectives: Diabetes is a complex chronic metabolic disorder. Today, many diabetes patients are known to supplement their standard therapies with herbal medications that have antidiabetic characteristics. The purpose of the study was examine fixed dose combination linagliptin and Emblica officinalis Gaertn (aq FE) for its hypoglycemic, hypolipidemic, antioxidant properties.
 Methods: Strep...

INTRODUCTION Dyslipidemia is one of the most common complications of diabetes mellitus, significantly contributing to cardiovascular morbidity and mortality in diabetic patients. Peucedanum pastinacifolium Boiss. & Hausskn. is commonly used as an antihyperlipidemic vegetable in Iranian folk medicine. MATERIAL AND METHODS In this study, we examined a hydroalcoholic extract of the aerial parts ...

Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme that consumes NAD in response to DNA strand breaks. Its excessive activation seems particularly deleterious to pancreatic beta-cells, as exemplified by the complete resistance of PARP-1-deficient mice to the toxic diabetes induced by streptozotocin. Because of the possible implication of this enzyme in type 1 diabetes, many human trials...

PURPOSE Oxidative stress is thought to contribute to diabetes-induced cataract, and the authors have previously demonstrated that lenses from mice lacking the antioxidant enzyme copper-zinc superoxide dismutase (SOD1) show elevated levels of superoxide radicals and are more prone in vitro to develop glucose-induced cataract than are wild-type lenses. In the present study the effect of streptozo...

Pharmacognosy Research,2022,14,2,225-232.DOI:10.5530/pres.14.2.32Published:April 2022Type:Original ArticleAuthors:Ram Niwas Jangir, and Gyan Chand Jain Author(s) affiliations:Ram Jain* Department of Zoology, University Rajasthan, Jaipur, INDIA. Abstract:Background: Diabetes mellitus (DM) is associated with reproductive impairment. Medicinal plants herbs are the rich source antioxidants which ma...

Introduction: Investigating the effects of colocynth pulp on levels of testosterone and changes in the reproductive system organs in streptozotocin-induced diabetic rats. Methods: In this study, 32 Wistar rats were divided into four groups of normal (N), normal+colocynth pulp (N+C), diabetic control (D), and diabetic+colocynth pulp (D+C). Groups N and D received orally 2 mL normal saline for tw...

The antioxidant effect of an aqueous extract of Phaseolus vulgaris pods, an indigenous plant used in Ayurvedic medicine in India, was studied in rats with streptozotocin-induced diabetes. Oral administration of Phaseolus vulgaris pod extract (PPEt; 200 mg/kg body weight) for 45 days resulted in a significant reduction in thiobarbituric acid reactive substances and hydroperoxides. The extract al...