. Abstrad This paper proposes a new Kalman Filter Recurrent Neural Network (I0 topology and a recursive Levenberg-Marquardt (L-M) second order learning algorithm capable to estimate parameters and states of highly nonlinear bioprocess in a noisy environment The proposed KFRNN identifier, learned by the Backpropagation and L-M learning algorithm, was incorporated in a direct adaptive neural cont...

The optimization of the operation of biological reactors is an interesting non-linear problem whose solution o!ers potential economic bene"t. We apply a peak seeking method to approach the maximum biomass production rate in a continuous stirred tank bioreactor. Two models, Monod and Haldane, are investigated and it is shown by simulation that the peak seeking scheme achieves optimization for bo...

This paper applied a new Kalman Filter Recurrent Neural Network (KFRNN) topology and a recursive Levenberg-Marquardt (L-M) learning algorithm capable to estimate parameters and states of highly nonlinear unknown plant in noisy environment. The proposed KFRNN identifier, learned by the Backpropagation and L-M learning algorithm, was incorporated in a direct and indirect adaptive neural control s...

Termitomyces clypeatus is a fungus species, which has been used as food and medicinal mushroom. In the current study, submersed fermentation of in stirred-tank bioreactor was determined for its culture biomass nutrient contents. T. obtained highest after from 13 to 15 days cultivation, when dry mycelium system more than 6%. Agitation speeds 150 or 180 rpm were most suitable fungus. The determin...

The studies on the alcoholic fermentation with immobilized S. cerevisiae cells on alginate using a bioreactor with stirred beds of biocatalysts indicated that the diffusion inside the biocatalyst particles attenuates or avoids the inhibitory effects, preserving the microbial activity. Using a mathematical model adequate for ethanol formation in heterogeneous systems the kinetic parameters V, KI...

This work was to investigate the hypoglycemic and antioxidant activities of the exopolysaccharides produced in a stirred-tank bioreactor by Inocutus hispidus. The exopolysaccharides showed significant antioxidant activities, up to 70.7±2.5% inhibition of hydroxyl radicals, 50% inhibition of 2,2-diphenyl-1-picrylhydrazyl radicals, and a Trolox equivalent antioxidant capacity of 3.3 mM. The exopo...

The engineering of functional smooth muscle (SM) tissue is critical if one hopes to successfully replace the large number of tissues containing an SM component with engineered equivalents. This study reports on the effects of SM cell (SMC) seeding and culture conditions on the cellularity and composition of SM tissues engineered using biodegradable matrices (5 x 5 mm, 2-mm thick) of polyglycoli...

Optimizing bioprocesses requires an in-depth understanding, from a bioengineering perspective, of the cultivation systems used. A characterization is typically performed via experimental or numerical methods, which are particularly well-established for stirred bioreactors. For unstirred, non-rigid such as wave-mixed bioreactors, methods prove to be problematic, often only simplified geometries ...