BACKGROUND Peanut allergy is an important health problem in the United States, affecting approximately 0.6% of children. Inadvertent exposure to peanut is a risk factor for life-threatening food-induced anaphylaxis. OBJECTIVE The purpose of this investigation was to develop an immunoassay for a major peanut allergen, Ara h 1, to detect peanut allergen in foods so that the risk of inadvertent ...

One of the major allergenic food or food constituent is peanut, in which a number of allergenic proteins have been described (Ara h1-9). Until now, the relative contribution of the individual peanut allergens to clinical food allergic responses is not known. Therefore, the present studies aimed to elucidate the relative contribution of Ara h1, 2, 3, and 6 to peanut allergy in a mouse model. For...

Aspergillus flavus is a soil fungus that commonly invades peanut seeds and often produces carcinogenic aflatoxins. Under favorable conditions, the fungus-challenged peanut plant produces and accumulates resveratrol and its prenylated derivatives in response to such an invasion. These prenylated stilbenoids are considered peanut antifungal phytoalexins. However, the mechanism of peanut-fungus in...

Genetic engineering offers great potential for developing peanut cultivars resistant to a broad spectrum of pathogens that pose a recurring threat to peanut health. In an effort to improve the disease resistance of peanuts, three transgenic peanut lines were developed. Somatic embryos of the peanut cultivar Okrun were transformed by inserting a chitinase gene from rice and/or a β-1-3-glucanase ...

BACKGROUND Lipid transfer protein (LTP) is a widely cross-reacting plant pan-allergen, and sensitized patients may react to many foods. Although peanut allergy is frequently reported by LTP-allergic patients, the evidence of the presence of an allergen homologous to LTP in peanuts is limited. OBJECTIVE To assess the prevalence of peanut allergy in patients sensitized to LTP, detect any allerg...

BACKGROUND The prevalence of peanut allergy has increased in developed countries, but little is known about developing countries with high peanut consumption and widespread parasitic infections. OBJECTIVE We sought to investigate peanut allergy in Ghana. METHODS In a cross-sectional survey among Ghanaian schoolchildren (n = 1604), data were collected on reported adverse reactions to peanut,...

Peanut allergy affects 1-2% of the world's population. It is dangerous, and usually lifelong, and it greatly decreases the life quality of peanut-allergic individuals and their families. In a word, peanut allergy has become a major health concern worldwide. Thirteen peanut allergens are identified, and they are briefly introduced in this paper. Although there is no feasible solution to peanut a...

BACKGROUND Many children develop a sensitization to peanut in early infancy, even before peanut is introduced in their diet. Sensitization is particularly common in young children with eczema. There have been scant data available to date on the sensitization pattern for specific peanut allergens in this patient group. The aim of this study was to investigate the allergen profile of infants and ...

BACKGROUND Peanut allergy is a major public health problem that affects 1% of the population and has no effective therapy. OBJECTIVE To examine the safety and efficacy of oral desensitization in peanut-allergic children in combination with a brief course of anti-IgE mAb (omalizumab [Xolair]). METHODS We performed oral peanut desensitization in peanut-allergic children at high risk for devel...

household cleaning agents (such as Formula 409 or even plain water) were used; however, dishwashing liquid left Ara h1 on 4 of 12 tables (possibly by leaving a film). Six schools were assessed without special prior preparation (2 used peanut-free tables/preparation areas, and 1 was totally peanut-free). Of the 6 preschools and schools evaluated, Ara h1 was found on 1 of 13 water fountains (130 ...