OBJECTIVE Myocardial involvement in systemic lupus erythematosus (SLE) has great importance. The aim of this study is to evaluate the rotation and twisting mechanics of the left ventricle (LV) in patients with SLE. METHODS Forty-three patients fulfilled at least four of the American College of Rheumatology criteria for SLE and 30 individuals as controls were included in the study. SLE disease...

Background Data are limited concerning the distribution of Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scores among patients with SLE in clinical practice and characteristics specific SLEDAI scores. Objectives To investigate patient demographics, status, treatment patterns, reported outcomes (PROs), overall stratified by score. Methods were drawn from Adelphi Real World IV (202...

Methods Cross-sectional study. 89 patients with diagnosis SLE (1986 ACR criteria) from a rheumatology center at a pediatric hospital were evaluated. Medical records were reviewed registering the following variables: sex, mean age, score SLEDAI, organ involvement, current pharmacological treatment and autoimmune profile. Descriptive analysis was done for qualitative and categorical variables (pe...

Background While treatment of Systemic lupus erythematosus (SLE) has substantially improved, a subset patients experiences severe progressive disease despite T- and B cell targeted therapy. Furthermore, drug-free remission seroconversion is difficult to achieve in SLE date Objectives To study the safety, tolerability, preliminary efficacy deep depletion using autologous CD19 chimeric antigen re...

OBJECTIVE The interleukin 17 (IL-17) cytokine family is involved in a number of chronic inflammatory diseases. In spite of contradictory findings and a lack of causality in clinical studies, IL-17 inhibition for systemic lupus erythematosus (SLE) has regained attention as a potential therapeutic pathway, after demonstrating disease-modifying capabilities in ankylosing spondylitis. We investigat...

OBJECTIVES To evaluate biomechanical and ultrasound (US) abnormalities in SLE patients as compared with controls and to assess the relationship between these abnormalities and SLE activity. METHODS Fifty-four consecutive female patients with SLE with and without foot pain and 60 female controls (30 with foot pain and 30 without foot pain) were recruited. SLE activity was assessed by the Syste...

The influence of co-existing atopy on the prognosis of juvenile systemic lupus erythematosus (JSLE) was assessed in this study. Patients diagnosed with JSLE between October 2005 and April 2016 were enrolled in a prospective study and followed up for 2 years. Management of patients was evaluated using the systemic lupus erythematosus disease activity index 2000 (SLEDAI-2K) score and laboratory v...

BACKGROUND Conventional magnetic resonance imaging (MRI) is the preferred neuroimaging method in the evaluation of neuropsychiatric systemic lupus erythematosus (NPSLE). The purpose of this study was to investigate the association between clinical and immunological features with MRI abnormalities in female patients with NPSLE, to screen for the value of conventional MRI in NPSLE. METHODS A to...

OBJECTIVES TO COMPARE TWO MEASURES OF SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) RESPONSE: the British Isles Lupus Assessment Group (BILAG)-based Composite Lupus Assessment (BICLA) and the Systemic Lupus Responder Index (SRI) against a clinician's assessment of improvement. METHODS Ninety-one lupus patients were identified with two visits at which Systemic Lupus Erythematosus Disease Activity Index (...