Our previous study revealed that newborns had a high level of absorption of human milk a-lactalbumin. [1] It decreased during the first month in the whole and nonallergic infants showed a 4fold reduction of gut permeability at 25-30 days of life. But patients with early allergic symptoms have increased gut permeability in comparison to non-allergic infants. In this study we examined gut permeab...

Collagen pentapeptide (Lys-Thr-Thr-Lys-Ser, KTTKS) and its palmitoylated derivative (pal-KTTKS) have received a great deal of attention as cosmeceutical ingredients for their anti-wrinkle effects. The objective of this study was to evaluate stability and permeability of KTTKS and pal-KTTKS in hairless mouse skin. In this study, a liquid chromatography-tandem mass spectrometric method was develo...

The aim of the present study was to investigate the relationship between the polar surface area and other molecular properties of the model drugs and their transdermal permeability across the rat skin. Few model drugs which are weakly acidic (ibuprofen, aceclofenac and glipizide) and weakly basic (olanzapine, telmisartan and sildenafil citrate) were selected for the study based on Polar surface...

the aim of the present study was to investigate the relationship between the polar surface area and other molecular properties of the model drugs and their transdermal permeability across the rat skin. few model drugs which are weakly acidic (ibuprofen, aceclofenac and glipizide) and weakly basic (olanzapine, telmisartan and sildenafil citrate) were selected for the study based on polar surface...

nowadays use of edible films and coatings is increasing due to their biodegradability properties. fish gelatin obtained from fish skin wastage can be used as an appropriate protein compound for preparation of edible films and replacing pork gelatin. in this study, films were prepared from a combination of fish gelatin and three phenolic compounds (caffeic acid, tannic acid and ferulic acid) at ...

The technology of fabricating microneedle arrays to deliver high molecular weight drugs across skin in a minimally invasive manner is receiving increasing attention. Microneedle arrays with different geometries have been manufactured using materials such as glass, polymer, metal, etc. However, a framework that can identify the optimum designs of these arrays seems to be lacking. This is importa...