This literature review presents data on the influence of serotonin metabolism bone tissue. The mechanisms by which affects formation and resorption bone, depending site synthesis (central or peripheral), as well cells receptor subtypes that are activated, have been considered. A number issues for further research highlighted, in particular, dose-response relationship side effects during chronic...

objective: serotonin reuptake inhibitors are frequently used in first-line treatments for patients ‎with obsessive-compulsive disorder. nevertheless, many of these patients do not ‎respond well to initial therapy. the hypothesis of glutamatergic dysfunction in specific ‎brain regions has been proposed in the pathophysiology of obsessive-compulsive ‎disorder. this study was designed to evaluate ...

Depression is an illness that causes symptoms in both the body and the brain, i.e., painful physical as well as emotional and vegetative symptoms. Ascending serotonergic and noradrenergic pathways may mediate the emotional and vegetative symptoms of depression and can potentially be targets of serotonin and norepinephrine reuptake inhibitors to obtain relief of these symptoms. Descending seroto...

Various studies suggest that selective serotonin reuptake inhibitors (SSRIs) may be useful in treating pathologic skin-picking. The authors investigated the effectiveness of fluoxetine in treating this behavior. Fifteen subjects with clinically significant skin-picking were recruited by newspaper advertisement. They received 6 weeks of open-label treatment with fluoxetine. Responders were then ...

The increasingly extensive use of selective serotonin reuptake inhibitors will probably increase the number of cases of cutaneous reactions due to these drugs. This report describes a case of generalized exanthema due to paroxetine. Positive results to patch tests indicated delayed hypersensitivity.

Use of selective serotonin reuptake inhibitors continues to increase, as does concern about previously unrecognized, subtle side effects and questions about whether these drugs produce effects on healthy subjects. The authors report novel emotional effects identified by an experienced, psychologically healthy meditator who is a psychiatrist and researcher. On a meditation retreat, the subject i...

Depression is a disabling condition resulting in significant impairment in social functioning, involving the patient's family, friends, work colleagues, and society at large. Although both psychologic and pharmacologic treatments generally improve many depressive symptoms, they do not always result in significant improvement in social functioning. The importance of recovery of social functionin...

B. Understand the indications, contraindications, efficacy, use, drug interactions, and side effects of classical and newer or alternative antidepressants for treating comorbid mood or anxiety disorders in patients with pain. This would include the use of first-generation agents (e.g., tricyclics, including nortriptyline and desipramine, and monoamine oxidase inhibitors, including phenelzine), ...

OCD is a syndrome characterized by obsessions and compulsions, as well other neuropsychiatric features, often associated with primary psychiatric disorders various neurologic conditions. If severe, can seriously interfere the patient’s quality of life. The mainstay treatment psychotherapy, especially cognitive-behavioural therapy, pharmacologic interventions, selective serotonin reuptake inhibi...