objective: hypoglycemia with multiple etiologies is a common in diabetic patients. the current study describes the probability of interaction between maprotiline, selective serotonine reuptake inhibitors like citalopram for induction of hypoglycemia. case presentation: a 47 year-old diabetic woman used tablet citalopram 20mg daily because of generalized anxiety disorder from two years ago, but ...

selective serotonin reuptake inhibitors (ssris) are reported to be associated with increased bleeding tendency. while findings of recent studies explain a lot about the pathophysiology of this side-effect, there is a general tendency to discontinue ssris as harmful medications. we report two instances of dose-dependent relations between sertraline and bleeding tendency. bleeding diathesis was a...

aim and background: considering the high frequency of anxiety and depressive symptoms in irritable bowel syndrome (ibs) patients, selective serotonin reuptake inhibitors (ssris) are recommended by some gastroenterologists for treatment. in this study, the efficacy of fluvoxamine on severity of symptoms and quality of life in ibs patients was assessed. methods and materials: a randomized, double...

objective: major depression is a mood disorder that causes changes in physical activity, appetite, sleep and weight. regarding the role of zinc in the pathology of depression, the present study was aimed to investigate the effects of zinc supplementation in the treatment of this disease. methods: this study was a double-blind randomized clinical trial. forty four patients with major depression ...

this meta-analysis aims to assess the efficacy and safety of ssris and tcas in treatment of pd. a computer-base search was conducted of pubmed, medline, embase, cochrane controlled trails register (cctr) up to december 2011. the random controlled clinic trials about ssris and tcas in pd treatment were collected. statistical analysis was completed using review manager, version 5.0. five clinic c...

Objectives: The purpose of the study was to assess the relationship between selective serotonin reuptake inhibitors use and hepatocellular carcinoma in Taiwan. Methods: Using the database of the Taiwan National Health Insurance Program, we conducted a case-control study to identify 4901 subjects aged 20 years and more with newly diagnosed hepatocellular carcinoma in 2000-2013 as the cases. We r...

It has long been postulated that a deficiency in CNS serotonergic activity is the cause of, or a predisposing factor for, depression. [1] However, the evidence for this association is largely circumstantial and it certainly does not represent an adequate and full model for depression, probably due to there being multiple aetiological factors. [2] Some pharmacological trial data also cast doubt ...