background: heat shock proteins (hsp) are highly conserved molecules with many immunological functions. they are highly immunogenic with important role in cancer immunotherapy and in vaccine development against infectious diseases. as adjuvant, hsp can augment the immunogenicity of weak antigens and can stimulate antigen presenting cells. although vaccines have been successful for many infectio...

BACKGROUND Previously, we had performed a clinical study using human leukocyte antigen (HLA)-A24-binding peptide vaccines containing a combination of novel cancer-testis antigens and anti-angiogenic peptides derived from DEPDC1, URLC10, FOXM1, KIF20A and VEGFR1 for advanced gastric cancer (AGC) patients who were refractory to chemotherapy. We applied the cocktail vaccine to the combination ther...

Pancreatic cancer represents the 4th leading cause of cancer deaths in the United States. Surgical resection remains the only potential curative approach. Current standard adjuvant therapy is gemcitabine monotherapy for 6 months. This year several trials investigated other combinations with or without molecular target agents, with or without concurrent radiation attempting to optimize adjuvant ...

BACKGROUND Although, in Western countries, oxaliplatin-based regimens have been established as a gold standard treatment for patients with stage III or high risk stage II colon cancer after curative resection, in Japan fluorouracil-based regimens have been widely accepted and recommended in the guidelines for adjuvant settings in patients with stage III colon cancer. S-1, an oral preparation ev...

In the present study the effect of the locally produced genetic adjuvant of ginea pig specific CpG-motif-containing oligodeoxynucleotide (CpG-ODN) in an inactivated FMD virus vaccine was evaluated. Boosting the ginea pigs with FMD vaccine along with CpG-ODN adjuvant produced relatively higher ratio (5-fold) of FMDV-specific IgG2a / IgG1 than those vaccinated in the absence of CpG-ODN. The neutr...

OBJECTIVES The aim of this study was to evaluate whether cardiac biomarkers, tissue velocity (TVI) and strain imaging, and cardiac magnetic resonance imaging can predict early left ventricular (LV) dysfunction in human epidermal growth factor receptor II-positive breast cancer patients treated with trastuzumab in the adjuvant setting. BACKGROUND Early indexes of LV systolic dysfunction with n...

The thesis is based on the following publications: 1. Ejlertsen B, Jensen MB, Mouridsen HT. Excess mortality in postmenopausal women who only receive adjuvant endocrine therapy for estrogen receptor positive breast cancer. Acta Oncol 2014;53:174-85. 2. Ejlertsen B, Jensen MB, Elversang J, Rasmussen BB, Andersson M, Andersen J, Nielsen DL, Cold S, Mouridsen HT. One year of adjuvant tamoxifen com...

despite the establishment of extensive and successful control programmes in some countries or regions, echinococcus granulosus still has a very wide geographical distribution. mature e. granulosus (n = 120) obtained from parasitology department, school of veterinary medicine, ferdowsi university of mashhad (iran). soluble protein of whole body of parasite was prepared by freeze-thawing in liqui...

BACKGROUND First-line postoperative adjuvant chemotherapies with S-1 and capecitabine and oxaliplatin (XELOX) were first recommended for resectable gastric cancer patients in the 2010 and 2011 Chinese NCCN Clinical Practice Guidelines in Oncology: Gastric Cancer; however, their economic impact in China is unknown. OBJECTIVE The aim of this study was to compare the cost-effectiveness of adjuva...

The immunogenicity of bacterial flagellin has been reported in different studies. By its close interaction with the immune system, the flagellin represents an interesting adjuvant and vaccine candidate. Salmonella Typhimurium flagellin has already been tested as adjuvant to stimulate mucosal immunity. Here, we assessed the ability of Clostridium difficile flagellin FliC to act as a mucosal adju...