17.7. Zeuzem S, Ghalib R, Rajender Reddy K, et al.Grazoprevir–elbasvir combination therapy for treatmentnaive cirrhotic and noncirrhotic patients with chronic HCVgenotype 1, 4, or 6 infection: a randomized trial. AnnIntern Med. Published online 24 April 2015doi:10.7326/M15-0785.8. Yeh WW. Drug-drug interactions withgrazoprevir/elbasvir: practical considerations for t...

Biological invasions are largely thought to be contemporary, having recently increased sharply in the wake of globalization. However, human commerce had already become global by the mid-16th century when the Spanish connected the New World with Europe and Asia via their Manila galleon and West Indies trade routes. We use genetic data to trace the global invasion of one of the world's most wides...

The p regression problem takes as input a matrix A ∈ Rn×d, a vector b ∈ Rn, and a number p ∈ [1,∞), and it returns as output a number Z and a vector xopt ∈ Rd such that Z = minx∈Rd ‖Ax− b‖p = ‖Axopt − b‖p. In this paper, we construct coresets and obtain an efficient two-stage sampling-based approximation algorithm for the very overconstrained (n d) version of this classical problem, for all p ∈...

Department of Pharmaceutical Chemistry, California Institute for Quantitative Biomedical Research, Mission Bay Genentech Hall, 600 16th Street, University of California, San Francisco, CA 94143-2240, USA Department of Biopharmaceutial Sciences, California Institute for Quantitative Biomedical Research, Mission Bay Genentech Hall, 600 16th Street, University of California, San Francisco, CA 9414...

OBJECTIVES To evaluate the clinical efficacy and tolerability of propiverine and solifenacin in female patients with overactive bladder (OAB). METHODS A prospective nonrandomized crossover study of propiverine 20 mg and solifenacin 5 mg was conducted. Female OAB patients were assigned alternately to treatment with propiverine for 8 weeks then solifenacin for 8 weeks (Group P-S) or solifenacin...

These highly informal lecture notes aim at introducing and explaining several closely related problems on zeros of analytic functions defined by ordinary differential equations and systems of such equations. The main incentive for this study was its potential application to the tangential Hilbert 16th problem on zeros of complete Abelian integrals. The exposition consists mostly of examples ill...

Within last century the study of cycles of twodimensional quadratic systems was stimulated by 16th Hilbert’s problem and its different variants [Hilbert, 1902; Lloyd, 1988; Blows & Perko, 1994; Ilyashenko, 2002; Chen & Wang, 1979; Shi, 1980]. The development of asymptotical methods for investigation of cycles of quadratic systems is facilitated by the fractionally-quadratic transformations, whi...