The essential Saccharomyces cerevisiae pre-messenger RNA splicing protein 24 (Prp24) has four RNA recognition motifs (RRMs) and facilitates U6 RNA base-pairing with U4 RNA during spliceosome assembly. Prp24 is a component of the free U6 small nuclear ribonucleoprotein particle (snRNP) but not the U4/U6 bi-snRNP, and so is thought to be displaced from U6 by U4/U6 base-pairing. The interaction pa...

To maximise the long-term use of limited ecosystem services in South Africa, managers continually require approaches to optimise the establishment of balances between the use and protection of ecosystems to ensure sustainability. Surface freshwater aquatic ecosystems are dynamic and difficult to manage effectively. Sound management protocols that can identify and rank threats to these ecosystem...

RNA recognition motifs (RRMs) constitute versatile macromolecular interaction platforms. They are found in many components of spliceosomes, in which they mediate RNA and protein interactions by diverse molecular strategies. The human U11/U12-65K protein of the minor spliceosome employs a C-terminal RRM to bind hairpin III of the U12 small nuclear RNA (snRNA). This interaction comprises one side...

Nowadays, the Long-Term Evolution-Advanced system is widely used to provide 5G communication due its improved network capacity and less delay during communication. The main issues in are insufficient user resources burst errors, because it creates losses data transmission. In order overcome this, an effective Radio Resource Management (RRM) required be developed network. this paper, Long Short-...

To meet the EU energy-saving and decarbonisation goals, need for automated processes building renovation increases. This paper demonstrates development of RINNO Retrofitting Manager (RRM) with web service technologies presents its functionalities. The main purpose this platform is to rationalise onsite execution retrofitting process so as enable optimising delivery works. RRM was co-developed a...

This paper proposes a Radio Resource Management strategy for unidirectional satellite systems delivering multicast and broadcast services to mobile users. Both the radio interface and the targeted services impose particular requirements on the RRM task. We present the individual RRM entities, describe their exact role and suggest algorithms for their functions.

The Drosophila sex determination gene Sex-lethal (Sxl) controls its own expression, and the expression of downstream target genes such as transformer , by regulating pre-mRNA splicing and mRNA translation. Sxl codes an RNA-binding protein that consists of an N-terminus of approximately 100 amino acids, two 90 amino acid RRM domains, R1 and R2, and an 80 amino acid C-terminus. In the studies rep...

Risk-reducing mastectomy (RRM) confers 90-95% decreased risk of breast cancer, and may reduce mortality, especially in high-risk groups such as BRCA carriers. Risk of occult disease in RRM specimen is ~5%. This demands axillary staging: sentinel lymph node (SLN) biopsy is no longer possible, axillary clearance confers significant risks and may prove negative. Contemporaneous SLN biopsy allows a...

Efficient editing of Trypanosoma brucei mitochondrial RNAs involves the actions of multiple accessory factors. T. brucei RGG2 (TbRGG2) is an essential protein crucial for initiation and 3'-to-5' progression of editing. TbRGG2 comprises an N-terminal G-rich region containing GWG and RG repeats and a C-terminal RNA recognition motif (RRM)-containing domain. Here, we perform in vitro and in vivo s...

Despite the importance of drivers’ actions and behaviors, underlying factors to those have not received adequate attention. Understanding contributing various before crashes could help policy makers take appropriate tackle behaviors occur. One first steps be identify by using a reliable statistical technique. It is reasonable assume that drivers vary in their decision-making processes. Thus, th...