Herein, Raman and surface-enhanced spectroscopies (SERS) were successfully employed to establish the chemical interactions of citrate-capped silver nanoparticles (AgNPs, 10–15 nm) with human red blood cells (RBCs). The Raman/SERS spectra offered spectral evidence for cellular uptake AgNPs subsequent change in conformation most abundant component, hemoglobin (Hb), from oxyhemoglobin deoxyhemoglo...

A computational scheme using the Chimera grid method is presented for simulation of three-dimensional motion and aggregation of two red blood cells (RBCs) in a narrow tube. The cells are modelled as rigid ellipsoidal particles; the computational scheme is applicable to deformable fluid-filled particles. Attractive energy between two RBCs is modelled by a depletion interaction theory and used fo...

Sickle cell disease (SCD) is an inherited blood disorder that affects red cells. The study was conducted in Elobied town during the period May 2011 to September 2011. aim of this detect abnormalities leucocytes among sickle anemic patients. 40 patients; age range between 8 months 23 years. Blood sample taken for all patients and laboratory investigation were performed using automated estimation...

Circulating tumor cells (CTCs), secreted from primary and metastatic malignancies, hold a wealth of essential diagnostic prognostic data for multiple cancers. Significantly, the information contained within these may key to understanding cancer metastasis, both individually fundamentally. Accordingly, developing ways identify, isolate interrogate CTCs plays an role in modern research. Unfortuna...

Yisui Shengxue granules, which is a Chinese traditional medicine, can increase hemoglobin, red blood cells, and Ret of thalassemia patients with mild, moderate, and severe anemia and thus relieve clinical anemia symptoms. Studies on mechanism found that Yisui Shengxue granules can increase the proliferation ability of hematopoietic stem cells. Emodin promoted colony forming of hematopoietic ste...

BACKGROUND Small animal models have been previously used in transfusion medicine studies to evaluate the safety of blood transfusion products. Although there are multiple studies on the effects of blood banking practices on human red blood cells (RBCs), little is known about the effect of blood component manufacturing on the quality of rat RBCs. METHODS Blood from Sprague-Dawley rats and huma...

We have recently shown that rosetting of Plasmodium falciparum (MC R+ line)-infected erythrocytes (parasitized red blood cells [PRBCs]) with uninfected erythrocytes (RBCs) is blocked by coating of the RBCs with anti-CD36 monoclonal antibodies (MoAbs; Handunnetti et al, Blood 80:2097, 1992). Adult RBCs have previously been considered negative for CD36. However, using fluorescence-activated cell ...

This article contains data on the variation in several physiological parameters of red blood cells (RBCs) donated by eligible glucose-6-phosphate dehydrogenase (G6PD) deficient donors during storage in standard blood bank conditions compared to control, G6PD sufficient (G6PD(+)) cells. Intracellular reactive oxygen species (ROS) generation, cell fragility and membrane exovesiculation were measu...

Central to the pathology of falciparum malaria is a reduction in the deformability of the infected red blood cells (RBCs). To enable improved methods to study this disease, we developed a microfluidic device to measure the deformability of infected cells. Individual RBCs are first infused into a series of funnel shaped constrictions. The deformability of individual cells is measured using the p...