BACKGROUND Tri-weekly and weekly regimens of paclitaxel have been reported to be effective in unresectable advanced or recurrent gastric cancer. The present study was conducted to determine the optimal dose of bi-weekly paclitaxel and evaluate safety and antitumor effect. PATIENTS AND METHODS The study included patients with a histologically confirmed diagnosis of advanced or recurrent gastri...

PURPOSE We investigated the efficacy and safety of a combination of oxaliplatin, 5-fluorouracil (5-FU), and folinic acid (FA) as first-line palliative chemotherapy for elderly patients with metastatic or recurrent gastric cancer. MATERIALS AND METHODS The study patients were chemotherapy-naïve patients (> 65 years old) with histologically confirmed, metastatic or recurrent gastric cancer. Che...

Objective: The aim of this study was to compare the cost-utility of S-1, an oral anticancer agent developed in Japan, and conventional intravenous chemotherapy in patients with advanced or recurrent gastric cancer on the basis of the cost and quality of life (QOL) data we previously reported. Methods: Patients with advanced or recurrent gastric cancer who could ingest food were identified retro...

background: gastric cancer is the second most common cause of death from cancer. as conflicting studies have recently been published, we aimed to evaluate the magnitude of the epidemiological evidence for an association between alcohol consumption and gastric cancer. methods: this study is a meta-analysis of case-control studies which have been performed during 1989 to 2007. we systematically r...

BACKGROUND Gastric cancer is the fourth most common cancer worldwide and more frequently detected in Asian countries including Korea and Japan. The incidence of young-age gastric cancer (GC) is increasing worldwide, but clinical behavior of young-age GC patients is not well established. We retrospectively analyzed the clinical features and outcomes of GC diagnosed at young-age population. MET...

background: this study testing the effectiveness ,toxicity and tolereability of new chemotherapeutic regimen (consist of irinotecan 5-fu and leucovorin) in locally advanced and metastatic gastric cancer. patients and methods: patients with locally advanced gstric cancer (atleast stage 3)or metastatic gastric cancer that no treated previously with chemotherapeutic agents entered onto this study....

cancer starts with a change in one single cell. this change may be initiated by external agents and genetic factors. cancer is a leading cause of death worldwide and accounts for 7.6 million deaths (around 13% of all deaths) in 2008. lung, stomach, liver, colon and breast cancer cause the most cancer deaths each year. in this review, different aspects of gastric cancer; including clinical, path...

helicobacter pylori (h.pylori) infection is probably the most important factor that has been associated with the development of gastric cancers in human populations. however, there are no reliable data on the prevalence of this infection in the middle east. in this article, based on a comprehensive literature review, we aimed to evaluate the situation in this region. the literature has been sea...