Over the past decade, significant advances have been made regarding the pathogenesis, clinical implications, and treatment of hyperuricemia. While physicians have understood for at least a century that uric acid causes gout, we are now beginning to address the question of why hyperuricemia exists and the mechanisms by which uric acid acts to stimulate inflammation. This review focuses on (1) pr...

CLIN. CHEM. 20/9, 1233-1234(1974) 3. Praetorius, E., and Paulsen, H., Enzymatic determination of uric acid with detailed directions. Scand. J. Clirz. Lab. Invest. 5, 273 (1953). 4. Feichtmeir, T. V., and Wrenn, H. T., Direct determination of uric acid using unease. Amer. J. Clin. Pathol. 25,833 (1955). 5. Liddle, L., Seegniiller, J. E., and Laster, L., The enzymatic spectrophotometric method fo...

In this issue of Leukemia and Lymphoma, Darmon et al. report that patients with renal injury manifest by an acute rise in serum creatinine or the development of oliguria without a rise in the serum creatinine (presumably insufficient time has elapsed for creatinine to accumulate in the serum) have a significantly shorter survival than patients who develop tumor lysis syndrome but maintain adequ...

TOPIC: Critical Care TYPE: Medical Student/Resident Case Reports INTRODUCTION: Acquired methemoglobinemia is a life-threatening cause of respiratory failure that occurs when there an increase rate oxidation hemoglobin to methemoglobin resulting in greater affinity for oxygen binding and decreased release the tissues (1). Rasburicase frequently used patients with tumor lysis syndrome. Methemoglo...