Alzheimer's disease (AD) is a degenerative brain with complex clinical manifestations and pathogeneses such as abnormal deposition of beta-amyloid protein inflammation caused by the excessive activation microglia. CXC motif chemokine receptor type 4 (CXCR4) G protein-coupled that binds to ligand 12 (CXCL12) activate downstream signaling pathways, Janus kinase/signal transducer activator transcr...

Background & Objectives: Anaplastic lymphoma Kinase (ALK) is a receptor tyrosine kinase involved in the genesis of several human cancers. ALK was initially identified because of its involvement in anaplastic large cell lymphoma (ALCL). ALK is believed to foster tumorigenesis following activation by autocrine and/or paracrine growth loops. Studies reveal that the presence of anti-ALK antibodies ...

introduction: atherosclerosis, hypertension, ischemic diseases, alzheimer’s disease, parkinson disease, cancer and inflammation emerge from imbalance between antioxidant and oxidants. cancer is a most important public health problem in both developed and developing countries. natural antioxidants such as polyphenols are being used for prevention and treatment cancer. polyphenols include phenoli...

Adenylate kinases (ADK) are ubiquitous enzymes that contribute to the homeostasis of adeninenucleotides in living cells. In this study, the cloning of a cDNA encoding an adenylate kinase from the filariaOnchocerca volvulus has been described. Using PCR technique, a 281 bp cDNA fragment encoding part ofan adenylate kinase was isolated from an O. volvulus cDNA library. Use of this fragment as a p...

The therapeutic effect of combined drugs on cervical cancer has been confirmed. Whether antiprogrammed cell death protein 1 antibody with paclitaxel mediates the phosphoinositide 3-kinase-protein kinase B pathway to regulate still needs further research. 20 nude mice received subcutaneous administration Henrietta Lacks cells establish model which was then assigned into blank control group, grou...

Background: Peripheral nerve injury (PNI) is a common condition that compromises motor and sensory functions. Peripheral nerves are known to have regenerative capability and the pineal hormone, melatonin, is known to aid nerve regeneration. However, the role of Schwann cells and the pathways involved remain unclear. Thus, the aim of this study is to identify the effects of melatonin on Schwann ...

Objective(s):Several investigations have revealed that caspase-14 is responsible for the epidermal differentiation and cornification, as well as the regulation of moisturizing effect. However, the precise regulation mechanism is still not clear. This study was aimed to investigate the expression of caspase-14 in filaggrin-deficient normal human epidermal keratinocytes (NHEKs) and to explore the...

a proteomic approach was conducted to further understand the mechanism of plant responses to salinity in hordeum bulbosom. three-week-old seedlings were treated with 300 mm of nacl for 21 days. total proteins of fourth leaf were extracted and separated by two-dimensional gel electrophoresis. more than 500 protein spots were reproducibly detected, including 46 spots that were up-regulated and 16...