نتایج جستجو برای: propoxy

تعداد نتایج: 252  

Journal: :Japanese journal of pharmacology 1973
T Ban

The antagonistic effects of two new ƒÀ-receptors blocking agents, Ko 1313 and Ko 1366 against the chronotropic and inotropic responses to noradrenaline and tyramine were studied on the isolated right and left atria of guinea-pigs. From the KB values estimated by means of three different methods, it was found that the potencies of KO 1366 were 5 to 10 times and 5 to 7 times those of Ko 1313 in t...

Burak Tüzün Emin Sarıpınar Sevtap Çağlar Yavuz

In this 4D-QSAR study, we obtained pharmacophore identification and biological activity prediction for 50 propoxy methylphenyl oxadiazole derivatives by the Electron Conformational Genetic Algorithm approach. In light of the results given in the data obtained from quantum chemical calculations at HF/3-21 G level, the electron conformational matrices of congruity (ECMC) were built by EMRE softwa...

Journal: :Antimicrobial agents and chemotherapy 1995
J Neyts G Jähne G Andrei R Snoeck I Winkler E De Clercq

The efficacy of 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine (S2242) was evaluated in several animal models for herpesvirus infections. Compound S2242 was more effective than acyclovir (i) when administered subcutaneously in a model for herpes simplex virus type 1 (HSV-1)-induced mortality in immunocompetent mice and (ii) when applied topically to hairless (hr/hr) mice that had been infect...

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