Although the diagnosis of Parkinson’s disease (PD) remains anchored around the cardinal motor symptoms of bradykinesia, rest tremor, rigidity and postural instability, it is becoming increasingly clear that the clinical phase of the disease is preceded by a long period of neurodegeneration, which is not readily evident in terms of motor dysfunction. The neurobiological mechanisms that underpin ...

OBJECTIVE To investigate the feasibility of microRNA (miRNA) levels in CSF as biomarkers for prodromal Huntington disease (HD). METHODS miRNA levels were measured in CSF from 60 PREDICT-HD study participants using the HTG protocol. Using a CAG-Age Product score, 30 prodromal HD participants were selected based on estimated probability of imminent clinical diagnosis of HD (i.e., low, medium, h...

INTRODUCTION Young and late onset patients with paranoid schizophrenia were compared, regarding the initial prodromal and active phases of the disorder, in order to examine the influence of age of onset on the prodromal and active phase symptomatology of the disease. MATERIALS AND METHODS We examined 88 consecutively hospitalized patients with paranoid schizophrenia. Age cutoff points were se...

Background/Objectives: Coronary heart disease (CHD) is the number one cause of death in women, yet, little is known about women's symptoms. Early symptom recognition of CHD in women is essential but most instruments do not assess both prodromal and acute CHD symptoms. Our aims were to develop an instrument validly describing women's prodromal and acute symptoms of myocardial infarction and to e...

Background and Purpose—Prompt recognition of stroke symptoms is critical to timely treatment and women have increased delay to treatment. Women may be more likely to present with atypical symptoms, but this hypothesis has not been extensively evaluated. Methods—We examined gender differences in the prevalence of presenting and prodromal stroke symptoms among 1107 consecutive patients hospitaliz...

s | 35 Abstract Due to familial factors, younger siblings of children with Autism Spectrum Disorder (ASD) are at an increased risk for developing the disorder1,2. Although behavioral symptoms of ASD typically emerge during a child’s second year,3 recent work on younger siblings demonstrates that prodromal features of ASD are present already within the first months of life. These features includ...

Background: Unstable angina and myocardial infarction are developed due to atherosclerosis of coronary arteries. At present, cholestrol, triglyceride, and lipoproteins are the most common risk factors of death. The purpose of this study was to assess the serum levels of LP (a), LDL-C, VLDL-C, HDL-C in cases of unstable angina and myocardial infarction.Methods: This study was conducted to compar...