نتایج جستجو برای: plc gene

تعداد نتایج: 1146437  

2014
John J. Gildea Ishan T. Shah Robert Van Sciver Jonathan A. Israel Christoph Enzensperger Helen E. McGrath Pedro A. Jose Robin A. Felder

Determining the individual roles of the two dopamine D1-like receptors (D1R and D5R) on sodium transport in the human renal proximal tubule has been complicated by their structural and functional similarity. Here we used a novel D5R-selective antagonist (LE-PM436) and D1R- or D5R-specific gene silencing to determine second messenger coupling pathways and heterologous receptor interaction betwee...

2016
Christine T. Lauren Nina K. Antonov Jean S. McGee David C. de Vinck Hanina Hibshoosh Marc E. Grossman

CTH2: caudal type homeobox gene 2 ER: estrogen receptor PLC: pleomorphic lobular carcinoma PR: progesterone receptor PSA: prostate-specific antigen TTF1: thyroid transcription factor

Introduction: Introduction: Molecular components within the microenvironment act upon cell growth, survival/apoptosis, and proliferation. Immune system cells respond to molecules produced by the tumor and released in the surrounding microenvironment, such as cytokines, chemokines, and growth factors. This study aimed to identify the effects of tumor environment on monocyte-macrophage cell linea...

Journal: :FEMS microbiology letters 2002
Kaori Ohtani Sushanta K Bhowmik Hideo Hayashi Tohru Shimizu

A novel gene that regulates the alpha-toxin (plc), kappa-toxin (colA), and theta;-toxin (pfoA) genes was identified using toxin-negative mutant strains of Clostridium perfringens. The cloned 3.2-kb fragment contained the virX gene encoding a 51-amino acid polypeptide of unknown function that seemed to be responsible for the activation of toxin genes. The virX knock out mutant of wild-type strai...

Journal: :the archives of bone and joint surgery 0
jorge chahla steadman philippon research institute, the steadman clinic, colorado, usa gilbert moatshe steadman philippon research institute, the steadman clinic, colorado, usa ------ orthopedic department, oslo university hospital, oslo, norway chase dean steadman philippon research institute, the steadman clinic, colorado, usa robert laprade steadman philippon research institute, the steadman clinic, colorado, usa

injuries to the posterolateral corner (plc) comprise a significant portion of knee ligament injuries. a high index of suspicion is necessary when evaluating the injured knee to detect these sometimes occult injuries. moreover, a thorough physical examination and a comprehensive review of radiographic studies are necessary to identify these injuries. in this sense, stress radiographs can help to...

Journal: :Frontiers in Oncology 2023

PLC-β is widely distributed in eukaryotic cells and the key enzyme phosphatidylinositol signal transduction pathway. The cellular functions regulated by its four subtypes (PLC-β1, PLC-β2, PLC-β3, PLC-β4) play an important role maintaining homeostasis of organism. related signals can promote or inhibit occurrence development cancer affecting growth, differentiation metastasis cells, while target...

2018
Zhi-Chao Xu Hao-Xin Shen Chen Chen Li Ma Wen-Zhi Li Lin Wang Zhi-Min Geng

As a co-receptor for a variety of cytokines, neuropilin-1 (NRP-1) is detectable in primary liver cancer (PLC) cells. Previous studies determined that silencing of NRP-1 expression attenuated the proliferation, migration and invasion of PLC cells. An increasing number of studies have highlighted the crucial role of the tumor microenvironment in the pathogenesis of cancer. Hepatic stellate cells ...

Journal: :International journal of oncology 2008
Takashi Goto Hiroki Ishikawa Kojiro Matsumoto Daisuke Nishimura Mariko Kusaba Naota Taura Hidetaka Shibata Hisamitsu Miyaaki Tatsuki Ichikawa Keisuke Hamasaki Kazuhiko Nakao Yohei Maeshima Katsumi Eguchi

Since hepatocellular carcinoma (HCC) is a hypervascular cancer, anti-angiogenic therapy is a promising approach to treat HCC. In the present study, we investigated the antiangiogenic and antitumor effects of tum-1, a fragment of tumstatin, gene transduction into HCC in vitro and in vivo. Tum-1 gene was cloned into a pSecTag2B mammalian expression vehicle to construct pSecTag2B-tum-1. pSecTag2B-...

Journal: :Plant physiology and biochemistry : PPB 2008
I Made Tasma Volker Brendel Steven A Whitham Madan K Bhattacharyya

Phosphoinositide-specific phospholipase C cleaves the substrate phosphatidylinositol 4,5-bisphosphate and generates inositol 1,4,5-trisphosphate and 1,2-diacylglycerol, both of which are second messengers in the phosphoinositide signal transduction pathways operative in animal cells. Five PI-PLC isoforms, beta, gamma, delta, epsilon and zeta, have been identified in mammals. Plant PI-PLCs are s...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه شیراز - دانشکده مهندسی برق و کامپیوتر 1391

امروزه در اکثر صنایع از کنترل کننده های قابل برنامه ریزی(plc) به علت مزایای زیادشان استفاده می شود. این سیستم ها جایگزین سیستم های رله ای قدیمی شده اند و با برنامه نویسی به شیوه های مختلف می توان بدون نیاز به تغییرات سخت افزاری در سیستم، تغییرات مورد نظر را برای فرآیند متصل به plc انجام داد. plcهای اولیه برای یک کنترل عادی منطقی و ساده طراحی گردیده اند و معمولا اجرای کنترل پیوسته ساده نیز با pl...

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