Nearly three decades have now passed since the discovery of the piracetam-like nootropics, compounds which exhibit cognition-enhancing properties, but for which no commonly accepted mechanism of action has been established. This review covers clinical, pharmacokinetic, biochemical and behavioural results presented in the literature from 1965 through 1992 (407 references) of piracetam, oxiraceta...

Several 4-substituted 1-acylpiperazines, obtained by molecular simplification of 4-substituted 1,4-diazabicyclo[4.3.0]nonan-9-ones, have been synthesized and tested in vivo on the mouse passive avoidance test, to evaluate their nootropic activity. The results show that, apparently, an N-acylpiperazine group can mimic the 2-pyrrolidinone ring of 1,4-diazabicyclo[4.3.0]nonan-9-one, as the compoun...

The effect of succinic salt diethylethanolamine fumaric ester on the cognitive abilities male CBA mice and outbred rats was studied. It found that test substance at doses 10 75 mg/kg in “Extrapolation escape task” has a positive short-term long-term memory animals, contributing to preservation reproduction information received. In “T-maze” test, both superior, it had comparable with reference d...