As part of our endeavor to enhance survival of natural product derived drug candidates and to guide the medicinal chemist to design higher probability space for success in the anti cancer drug development area, we embarked on a detailed study of the property space for a collection of natural product derived anti cancer molecules. We carried out a comprehensive analysis of properties for 24 natu...

Abstract Objective: To analyze the in vitro effectiveness of cellulose nanocrystals (CNC) inducing pro-inflammatory and immune adjuvant effects THP-1 cells, a monocyte cell line isolated from peripheral blood an acute monocytic leukemia patient. Methods: cells were counted, their viability was calculated followed by quantification IL-1 β production. Results: We observed following: 1) CNCs not c...

Abstract. Pato U, Ayu DF, Riftyan E, Restuhadi F, Pawenang WT, Firdaus R, Rahma A, Surono IS, Jaswir I. 2021. Physicochemical property of oil palm leaves and utilization cellulose microfiber as probiotic encapsulant. Biodiversitas 22: 2937-2944. The vast land (Elaeis guineensis) in Indonesia has a huge potential for solid waste, which can be used various human needs. physiochemical analysis per...

Aminoamide local anesthetics induce vasoconstriction in vivo and in vitro. The goals of this in vitro study were to investigate the potency of local anesthetic-induced vasoconstriction and to identify the physicochemical property (octanol/buffer partition coefficient, pKa, molecular weight, or potency) of local anesthetics that determines their potency in inducing isolated rat aortic ring contr...

Because of its outstanding thermochromic characteristics and metal-insulator transition (MIT) property, nano-vanadium dioxide (abbreviated as nano-VO2 or nVO2) has been applied widely in electrical/optical devices and design of intelligent window. However, the biological effect of nVO2 is not well understood, especially when affected by environmental factors or living organisms. For VO2 is an a...