The impact of pentylenetetrazol-induced kindling on the effectiveness of theta pattern primed-bursts (PBs) for the induction of long-term potentiation (LTP) of field excitatory postsynaptic potentials (fEPSP) and population spikes (PS) were investigated in hippocampal CA1 of pentylenetetrazol-kindled rats in vivo. The results showed that shortly after kindling, control animals had normal LTP of...

The impact of pentylenetetrazol-induced kindling on the effectiveness of theta pattern primed-bursts (PBs) for the induction of long-term potentiation (LTP) of field excitatory postsynaptic potentials (fEPSP) and population spikes (PS) were investigated in hippocampal CA1 of pentylenetetrazol-kindled rats in vivo. The results showed that shortly after kindling, control animals had normal LTP of...

The purpose of this study was to determine if aversive effects of alcohol withdrawal could be detected in mice using the place conditioning procedure and whether the GABA(A) receptor antagonist, pentylenetetrazol (PTZ), would increase the aversive effects of alcohol withdrawal and increase the probability of detecting conditioned place aversion. Subjects were alcohol-naïve mice from a specific ...

We observed a 69 year old patient who had spontaneous paroxysmal attacks of weeping with lacrimation, contorted facies, and (usually) head-turning to the right. These episodes were followed by confusion and amnesia. During a pentylenetetrazol-evoked attack the EEG showed a right temporal delta rhythm. Atrophy, particularly of the right temporal regions, was noted on pneumoencephalography. We pr...

A dichloromethane extract from leaves of Searsia pyroides potentiated gamma aminobutyric acid-induced chloride currents by 171.8 ± 54% when tested at 100 µg/mL in Xenopus oocytes transiently expressing gamma aminobutyric acid type A receptors composed of α1β2γ2s subunits. In zebrafish larvae, the extract significantly lowered pentylenetetrazol-provoked locomotion when tested at 4 µg/mL. Active ...

Anticonvulsant action of vigabatrin (300, 600, 900 and/or 1200 mg/kg i.p.), an inhibitor of GABA-transaminase, was studied in a model of motor sezures elicited by pentylenetetrazol. Five age groups of rats (7, 12, 18, 25 and 90 days old) received a s.c. injection of pentylenetetrazol 4, 6 and/or 24 hours after vigabatrin administration. The incidence of minimal, predominantly clonic seizures wa...

The intravenous pentylenetetrazol (i.v.PTZ) seizure test provides threshold dose for induction of seizures in individual animals. In the present study, the i.v. and s.c.PTZ seizure models in mice were compared for seizure pattern, intra- and interanimal variability. Anticonvulsant activities of several antiepileptic drugs (AEDs) at non-ataxic dose levels were evaluated in the PTZ and maximal el...