Background: Alkaloid drugs were permitted for using as a treatment of numerous diseases. Colchicine, codeine, piperine, papaverine, ergometrine, theophylline, theobromine and caffeine are recognized safe alkaloids used many human disfunctions. The chemical structures have flexible moieties with various electronic characters. COVID-19 is horrible disease result from that the discovering potent p...

Effects of nonspecific smooth muscle relaxants, papaverine (10(-4) M) and Aspaminol (1,1-diphenyl-3-piperidinobutanol hydrochloride, 10(-4) M), and Ca-blocker, D-600 (10(-6) M) on Ca-release and Ca-binding in the microsomal fractions of rabbit taenia coli were determined. The doses necessary to relax the K-depolarized taenia coli were determined. The doses necessary to relax the K-depolarized t...

OBJECT The goal in this study was to determine if there was a change in intracranial venous diameters after endovascular treatment of carotid distribution vasospasm caused by subarachnoid hemorrhage. METHODS The venous diameters were measured in all patients who received intraarterial papaverine and/or balloon angioplasty for treatment of vasospasm during the study period of 3 years. To evalu...

OBJECTIVES To evaluate the therapeutic effect of papaverine hydrochloride in the treatment of patients with renal colic pain unresponsive to conventional treatment. METHODS From March 2007 to January 2008, a total of 561 patients with severe renal colic pain due to a ureteral stone were treated with conventional agents (hyoscine-N-butylbromide and diclofenac sodium) in the emergency and urolo...

OBJECTIVE The goal of the present study was to formulate topical nanocarriers of the low-cost vasodilator, papaverine hydrochloride (PH), as an alternative to the painful penile injections. The injections are used for both diagnosis and treatment of erectile dysfunction. Transdermal nano-transferosome (T), the ultraflexible nanoliposome, was used as a nanocarrier to enhance the penetration of t...

Cancer cells are often immortal through up-regulation of the hTERT gene, which encodes the catalytic subunit of a special reverse transcriptase to overcome end-replication problem of chromosomes. This study demonstrates that papaverine, an isoquinoline alkaloid from the Papaveraceae, can overcome telomerase dependent immortality of HepG-2 cells that was used as a model of hepatocarcinoma. Altho...

Many pathological changes in the retina which give rise to visual deterioration are caused by circulatory disturbances. A number of vaso-active substances have been suggested for the treatment of these disorders in an attempt to increase the flow of blood through the eye. One such substance is papaverine which has been used in the management of acute occlusions of the central retinal artery (Va...

BACKGROUND AND PURPOSE Angioplasty and intra-arterial papaverine are promising treatments for severe symptomatic vasospasm after subarachnoid hemorrhage (SAH), but there is little information on the clinical factors that predict treatment outcome. We sought to determine variables for predicting functional outcome in this setting. METHODS We reviewed 81 consecutive patients with symptomatic ce...

Background. Experimental data demonstrate the persistence of a transmural vasodilator reserve in the face of depressed resting myocardial perfusion. The present study was designed to determine whether resting myocardial hypoperfusion indicates exhausted coronary reserve (CR). Methods and Results. Fifteen patients with stable angina, isolated left anterior descending coronary artery (LAD) stenos...

Although augmentation of flow does not improve the performance of normal myocardium, the hyperemic response after brief coronary occlusion is associated with transient hyperfunction in the previously ischemic region. In this study we assessed the effect of vasodilator-enhanced coronary blood flow on the systolic function of postischemic stunned myocardium. In 18 open-chest, anesthetized dogs th...