The plasma concentrations of pancuronium were monitored during i.v. infusions of the relaxant in dogs. Pancuronium was administered at rates which maintained the degree of neuromuscular blockade at three predetermined levels. The concentrations of the drug in the blood were consistent for any one animal but showed considerable overlap for the three levels of paralysis between animals. Concentra...

A case report is presented in which an asthmatic patient appears to have developed bronchospasm after being given pancuronium. A review of the literature indicates that this agent is the least likely of muscle relaxants in clinical use to provoke such a response, and that no such case has hitherto been reported. It is suggested that caution should be exercised even when pancuronium is used in a...