Background and Objective: P53 is a suppressive gene that plays a key role in DNA repair and apoptosis. The purpose of this study was to investigate the effect of P53 protein over-expression and some clinicopathological factors on the esophageal squamous cell carcinoma (SCC) response to neoadjuvant chemoradiotherapy. Patients and Methods: In this retrospective cohort study, 44 patients with loc...

Objective(s): Hyperglycemia induces cellular senescence in various body cells, such as vascular endothelial cells. Since the vessels are highly distributed in the body and nourish all tissues, vascular damages cause diabetes complications such as kidney failure and visual impairment. Alpha-mangostin is a xanthone found in mangosteen fruit with protective effects in met...

the proliferation of hepatocellular carcinoma (hcc) cells is one of the leading causes of liver cancer mortality in humans. the inhibiting effects of matrine on hcc cell proliferation have been studied, but the mechanism of that inhibition has not been fully elucidated. since, apoptosis plays an important role in hcc cell proliferation. we examined the apoptosis-inducing effect of matrine on tu...

objective(s):intermittent hypoxia (ih), caused by obstructive sleep apnea (osa), could cause hippocampus or neuron damage through multiple signaling pathways, while the underlying mechanisms are still unclear. thus, the present study aimed to explore the effect of ih on the biological functions of microglia cells. materials and methods:cell proliferation of bv2 cells after exposure to ih were o...

Summary p53-binding protein 1 (53BP1) regulates both the DNA damage response and p53 signaling. Although 53BP1's function is well established in double-strand break repair, how its role signaling modulated remains poorly understood. Here, we identify scaffolding AHNAK as a G1 phase-enriched interactor of 53BP1. We demonstrate that binds to 53BP1 oligomerization domain controls multimer...

Abstract The pro-oncogenic activities of estrogen receptor alpha (ER) drive breast cancer pathogenesis. Endocrine therapies that impair the production or action ER are therefore used to prevent primary disease metastasis. Although recent successes with degraders have been reported, there is still need develop further antagonists additional properties for therapy. We previously described a ben...

Hepatocellular carcinoma is the fourth cause of death due to cancer and includes 90% liver tumors. Therefore, in this study, it was tried show that Althaea officinalis L. flower extract (ALOF) can protect hepatocytes against N-diethylnitrosamine (DEN)-induced hepatocellular carcinoma. Totally, 70 Wistar rats were divided into seven groups (n = 10/group) sham, DEN, treatment with silymarin (SIL;...

P53 is a recognized tumor suppressor gene, which mainly depends on the activity of its transfer factor to realize effect. Mouse two-minute 2 (MDM2) an important inhibitor p53. When combined with MDM2, p53 will be reduced, and anti-cancer effect weakened. According mechanism between researchers focus inhibitors inhibit their binding. Through large number drug screening methods means, this articl...