نتایج جستجو برای: organotin
تعداد نتایج: 771 فیلتر نتایج به سال:
The series of 14 complex organotin(IV) compounds containing many tin atoms and noncovalent bonds in the structure was characterized by electrospray ionization multistage tandem mass spectrometry (ESI-MS(n)). The mass spectra were measured in both polarity modes to obtain complementary structural information. The characteristic pattern of ten natural tin isotopes allowed the determination of the...
Six diorganotin(IV) carboxylates prepared by reacting diorganotin(IV) dichlorides with the respective silver carboxylate have been tested for antifungal activity against Aspergillus. niger, Aspergilluus flavus and Pencillium. citrinum in Sabourand dextrose broth. The compounds generally exhibit greater fungitoxicity than the diorganotin(IV) dichlorides and the carboxylic acids from which they w...
Organotin compounds such as triphenyltin (TPT) and tributyltin (TBT) act as endocrine disruptors through the peroxisome proliferator-activated receptor γ (PPARγ) signaling pathway. We recently found that TPT is a particularly strong agonist of PPARγ. To elucidate the mechanism underlying organotin-dependent PPARγ activation, we here analyzed the interactions of PPARγ ligand-binding domain (LBD)...
Nuclear receptors play important roles in the maintenance of the endocrine system, regulation of organ differentiation, and fetal development. Endocrine disruptors exert their adverse effects by disrupting the endocrine system via various mechanisms. To assess the effects of endocrine disruptors on nuclear receptors, we developed a high-throughput method for identifying activators of nuclear re...
Abstract Organotin compounds are widely employed as pesticides and fungicides in agriculture stabilizers for the industrial manufacture of polyvinyl chloride other polymers. Accordingly, these endocrine disruptors can be found a variety foods beverages. In present study, we describe optimization hollow-fiber liquid-phase micro-extraction approach simultaneous derivatization, extraction, pre-con...
3-(2-Furanyl)-2-propenoic acid has been used to prepare a new series of organotin complexes of general formula R3SnL (R=Me, Et, n-Bu, Ph and Cy) and R2SnL2 (R=Me and n-Bu). These complexes have been characterized by elemental analyses, IR, 1H-NMR, MASS and Mössbaure spectroscopy.
Organotin(IV) compounds show great potential as antitumor metallodrugs with lower toxicity and higher antiproliferative activity. Histone deacetylases (HDAC) inhibitors are characterized by high bioavailability low toxicity. In this contribution, the two novel octahedral organotin(IV) complexes of physiologically active hydroxamate-based ligands, N-hydroxy-4- phenylbutanamide (HL1) N-hydroxy-2-...
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