نتایج جستجو برای: oncogene proteins
تعداد نتایج: 570601 فیلتر نتایج به سال:
The ability of host cells to activate apoptosis is perhaps the most potent weapon for helping eliminate viruses. Human papillomaviruses (HPV) several pathways, enabling infected avoid extrinsic and intrinsic pathways. incapacity prostatic epithelial induce leads invasive development prostate cancer. For pathogenesis cancer, risk factors have been reported; example, some viruses infectious disea...
The isoprenoid pathway in FRTL-5 thyroid cells was found to be deeply altered on transformation with v-K-ras. A dramatic overall reduction of protein prenylation was found in v-K-ras-transformed cells in comparison with the parent FRTL-5 cells, as shown by labeling cells with [3H]mevalonic acid. This phenomenon was accompanied by a relative increase of p21(ras) farnesylation and by a decrease o...
Highly steroidogenic granulosa cell lines were established by transfection of primary granulosa cells from preovulatory follicles with SV40 DNA and Ha-ras oncogene. Progesterone production in these cells was enhanced to levels comparable to normal steroidogenic cells, by prolonged (> 12 h) stimulation with 8-Br-cAMP, forskolin and cholera toxin, which elevate intracellular cAMP. The steroidogen...
Glioblastoma multiform(GBM) is the most prevalent primary brain tumor. Exosomes are extracellular vehicles for exchanging information between various cell types including cancer and normal cells. Exosomes are indicative of pathophysiological conditions of brain tumors that could be used in diagnosis and prognosis of GBM. In tumors, exosomes could carry various molecules like several miRNAs and ...
background & objective: the current approaches to reduce the risk of colorectal carcinoma are through the detection and removal of the precursor lesion” adenomatous polyps”. the study was conducted to evaluate the immunohistochemical expression of p53 and bcl2 in colorectal adenomas and carcinomas. patients and methods: a total of 86 cases, 33 colorectal adenomas, 33 colorectal adenocarcin...
The introduction of small-molecule drugs and humanized monoclonal antibodies as novel therapies that target specific receptors and proteins in specific signal-transduction pathways has renewed interest in genes that had previously been identified as being involved in the tumorigenic process. The first of these genes was the ERBB2 [v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro...
background neuroblastoma is the most common extracranial malignant solid tumor in children under 5 years, and it is characterized by wide clinical and biological heterogeneity. n-myc oncogene amplification is considered to be one of the most important prognostic factors used to evaluate survival in these patients. objectives the aim of our study was to determine amplification of the n-myc oncog...
TWIST1, an epithelial-mesenchymal transition (EMT) transcription factor, is critical for oncogene-driven non-small cell lung cancer (NSCLC) tumorigenesis. Given the potential of TWIST1 as a therapeutic target, a chemical-bioinformatic approach using connectivity mapping (CMAP) analysis was used to identify TWIST1 inhibitors. Characterization of the top ranked candidates from the unbiased screen...
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