نتایج جستجو برای: nucleosides
تعداد نتایج: 10296 فیلتر نتایج به سال:
Fluorescent nucleic acid base analogues and the corresponding nucleosides that reveal excited-state proton transfer, including phototautomerism, are briefly characterized, and their potential applications as fluorescent probes discussed. Among the most promising systems are formycins and some 8-azapurines as well as the corresponding nucleosides, like 8-azaxanthosine. Other, nonfluorescent syst...
A facile and general procedure for the preparation of alkynyl C-nucleosides with varied fluorophores is presented. Sonogashira coupling was used as a key reaction to conjugate the dyes to an easily accessible ethynyl functionalized deoxyribose derivative. The new C-nucleosides were used for the preparation of DNA-based polyfluorophores.
beta-L-2',3'-Dideoxycytidine (beta-L-ddC) and beta-L-5-fluoro-2',3'-dideoxycytidine (5-F-beta-L-ddC) were prepared and shown to have potent activity against human immunodeficiency virus type 1 (HIV-1) and hepatitis B virus (HBV). These compounds were compared with beta-D-2',3'-dideoxycytidine (beta-D-ddC) and two beta-L-oxathiolane nucleosides (beta-L-3'-thio-2',3'-dideoxycytidine and beta-L-5-...
ducing carcinostasis, with tumor cells resistant to thio guanine, has been suggested (9). The aand @9-anomers of 2'-deoxythioguanosine (TGDR) have been shown to be active against ascites tumors having either of two types of resistance to thioguanine (10). The kinases necessary for conversion of these nucleosides to nucleotides were apparently present in the tumor cell lines examined. How ever, ...
A liquid chromatography-triple-quadrupole linear ion trap mass spectrometry (LC-QTrap-MS) analysis has been developed for the identification and quantification of 10 nucleosides and nucleobases in extracts of Antrodia camphorata. The method was successfully used to qualitatively identify for six nucleosides namely, cytidine, uridine, inosine, guanosine, thymidine, adenosine and four nucleobases n...
RNA contains a large number of modified nucleosides. In the metabolic re-exchange of RNA, modified nucleosides cannot be recycled and are thus excreted from cells into biological fluids. Determination of endogenous modified nucleosides in biological fluids may serve as non-invasive cancers diagnostic methods. Here we prepared boronate-affinity organic-silica hybrid capillary monolithic column (...
the synthesis of 5' - deoxynucleoside 5' - phosphonates which contains a 5' - cp bond in place of the 5' -cop bond of the naturally occuring nucleotides is described. the preparation of phosphonate derivatives of acyclo - nucleosides and a simple method for the conversion of 1-? -d-ribofuranosyl pyrimidines to the corresponding 1-? -d-arabinofuranosyl pyrimidines are also ex...
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