نتایج جستجو برای: normoxia

تعداد نتایج: 2771  

2016
Laurent Lemaire Janske Nel Florence Franconi Guillaume Bastiat Patrick Saulnier

Growing tumor cell lines, such as U87-MG glioma cells, under mild hypoxia (3% O2) leads to a ca. 40% reduction in growth rate once implanted in the brain of nude mice, as compared to normoxia (21% O2) grown cells, wherein the former over-express HIF-1 and VEGF-A. Despite developing differently, the tumors have similar: blood perfusion, oxygen consumption, and vascular surface area parameters, w...

2013
Natalia de Isla Céline Huselstein Didier Mainard Jean-François Stoltz

The aim of this work was to develop an in vitro model to study mechanical compression effects on cartilage. A pressure-controlled compression device was used in this study. Cartilage explants obtained from human knee were compressed at 1MPa/1Hz for 7 hours (30 min ON, 30 min OFF) under normoxia (5% CO2, 21% O2) or hypoxia (5% CO2, 5% O2). Cell viability was analyzed while nitric oxide (NO) and ...

2013
ALLAN J. HANCE EUGENE D. ROBIN M. SIMON SVETLANA ALEXANDER LEONORE A. HERZENBERG JAMES THEODORE

content in L2 lung cells and WI-38 fibroblasts cultivated under hypoxic and normoxic conditions. After 96 h of hypoxic cultivation, PyKi activity was significantly increased in both cell types (L2: normoxia [Po2 = 142 torr], 0.11+0.01 [SD]; hypoxia [Po2 = 14 torr], 0.25 ±0.04 U/,ug DNA, P < 0.01). PyKi content increased proportionately in both cell lines (L2: normoxia, 0.44 +0. 13; hypoxia, 0.9...

Journal: :Journal of applied physiology 2000
J P Mortola E L Seifert

Because the circadian rhythms of oxygen consumption (VO(2)) and body temperature (T(b)) could be contributed to by differences in thermogenesis and because hypoxia depresses thermogenesis in its various forms, we tested the hypothesis that hypoxia blunts the normal daily oscillations in VO(2) and T(b). Adult rats were instrumented for measurements of T(b) and activity by telemetry; VO(2) was me...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2011
Keisho Katayama Koji Ishida Erika Iwamoto Motoyuki Iemitsu Teruhiko Koike Mitsuru Saito

It was demonstrated that acute hypoxia increased muscle sympathetic nerve activity (MSNA) by using a microneurographic method at rest, but its effects on dynamic leg exercise are unclear. The purpose of this study was to clarify changes in MSNA during dynamic leg exercise in hypoxia. To estimate peak oxygen uptake (Vo(2 peak)), two maximal exercise tests were conducted using a cycle ergometer i...

Journal: :International journal of molecular medicine 2012
Anika Jonitz Katrin Lochner Thomas Tischer Doris Hansmann Rainer Bader

To prevent de-differentiation of chondrocytes in vitro, the 3D environment, growth factors and different oxygen concentrations were considered. In this in vitro study, we quantified the influence of insulin-like growth factor (IGF)-1 and/or transforming growth factor (TGF)-β1 under differing oxygen (5/21% O(2)) levels on the proliferation and synthesis rates of hyaline extracellular matrix (ECM...

2014
Matthew E. Pamenter Jetson Nguyen John A. Carr Frank L. Powell

Ventilatory acclimatization to hypoxia (VAH) increases the hypoxic ventilatory response (HVR) and causes persistent hyperventilation when normoxia is restored, which is consistent with the occurrence of synaptic plasticity in acclimatized animals. Recently, we demonstrated that antagonism of individual glutamate receptor types (GluRs) within the nucleus tractus solitarii (NTS) modifies this pla...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2011
Dominik Pesta Florian Hoppel Christian Macek Hubert Messner Martin Faulhaber Conrad Kobel Walther Parson Martin Burtscher Michael Schocke Erich Gnaiger

Endurance and strength training are established as distinct exercise modalities, increasing either mitochondrial density or myofibrillar units. Recent research, however, suggests that mitochondrial biogenesis is stimulated by both training modalities. To test the training "specificity" hypothesis, mitochondrial respiration was studied in permeabilized muscle fibers from 25 sedentary adults afte...

Journal: :American journal of physiology. Heart and circulatory physiology 1999
R S Richardson H Wagner S R D Mudaliar R Henry E A Noyszewski P D Wagner

Vascular endothelial growth factor (VEGF) is involved in extracellular matrix changes and endothelial cell proliferation, both of which are precursors to new capillary growth. Angiogenesis is a vital adaptation to exercise training, and the exercise-induced reduction in intracellular[Formula: see text] has been proposed as a stimulus for this process. Thus we studied muscle cell[Formula: see te...

Journal: :Journal of applied physiology 2013
Thomas Rupp Marc Jubeau Guillaume Y Millet Stéphane Perrey François Esteve Bernard Wuyam Patrick Levy Samuel Verges

Performing exercise during the first hours of hypoxic exposure is thought to exacerbate acute mountain sickness (AMS), but whether this is due to increased hypoxemia or other mechanisms associated with exercise remains unclear. In 12 healthy men, AMS symptoms were assessed during three 11-h experimental sessions: 1) in Hypoxia-exercise, inspiratory O(2) fraction (Fi(O(2))) was 0.12, and subject...

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