it has been well documented that preeclampsia (pe) has a common etiological background, but little is known about its linkage at the molecular level.non- coding rnas are critical posttranscriptional regulators ofgene expression.  this study was performed to determine whether peis associated with alterations in placental non-codingrnas expression. microrna(mir)-155-5p and long non-coding rna (ln...

Emerging evidence implicates that a large fraction of human genome was transcribed but the transcripts known as long non coding RNA are not translated into proteins. They are contributing in different cellular processes, including cellular proliferation and apoptosis. LncRNAs were found to play critical roles in many diseases and act as key regulators in malignancies. In this study, we investig...

Precise interpretation of the transcriptome sequences in the several species showed that the major part of genome has been transcribed; however, just a few amounts of the transcription sequences have open-reading frames which are conversed during the evolution. So, it is unlikely that many of the transcribed sequences code the proteins. Among the all human non-coding transcripts, at least 10000...

Background: Despite recent advances in diagnosis and treatment, breast cancer remains a leading cause of death in women worldwide. Long non-coding RNAs are a new class of RNA molecules that have been shown to participate in tumorigenesis. The aim of this study was to investigate the expression of lncUSMycN in tumor samples and to evaluate its potential role in the breast cancer cell line. Metho...

micrornas constitute a group of small non-coding rnas that negatively regulate gene expression. aside from their contribution to biological and pathological pathways, altered expression of micrornas is reported in bio-fluid samples, such as serum. to employ serum's micrornas as potential biomarkers, it is crucial to develop an efficient method for microrna quantification, avoiding pre-analytica...

DNA double strand breaks (DSBs) are abrasions caused in both strands of the DNA duplex following exposure to both exogenous and endogenous conditions. Such abrasions have deleterious effect in cells leading to genome rearrangements and cell death. A number of repair systems including homologous recombination (HR) and non-homologous end-joining (NHEJ) have been evolved to minimize the fatal effe...