Environmental Health Perspectives • volume 119 | number 8 | August 2011 A 331 and are uncertain about why community members are dying from what appear to the survivors to be unusual causes. Although Hrudey may feel this concern is misplaced or unfounded, that opinion does not reflect the feelings of those who live in Fort Chipewyan. The Alberta government’s assertion that more extensive health ...

Understanding the relationship between the molecular mechanisms underlying neurotoxicity of high-dose methamphetamine (METH) and related clinical manifestations is imperative for providing more effective treatments for human METH users. This article provides an overview of clinical manifestations of METH neurotoxicity to the central nervous system and neurobiology underlying the consequences of...

5. Introduction ............................................................................................................................................. The effects of continuous amphetamine administration on brain and behavior (amphetamine neurotoxicity) ..................... The behavioral consequences of repeated intermittent amphetamine administration (behavioral sensitization) ..........

Behavioral end points for neurotoxicity risk assessment have been developed and examined over the past three decades. They are now ready to move from simple qualitative guidelines, such as exemplified by reference doses, to more quantitative models, such as benchmark doses, based on dose-response information. Risk assessors, confronted by a wider array of methodologies and data than in the past...

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . I Acknowledgements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . II

BACKGROUND In cancer care, mobile phone-based systems are becoming more widely used in the assessment, monitoring, and management of side effects. OBJECTIVE To explore the experiences of patients with colorectal cancer on using a mobile phone-based system for reporting neurotoxic side effects. METHODS Eleven patients were interviewed (ages 44-68 years). A semistructured interview guide was ...

The development of the central nervous system and various pathological contexts imply remodeling or alteration of neuronal networks associated with tissue recruitment of mononuclear phagocytes. Purification and culture of brain macrophages have provided a tool for investigating the functions of these cells. We discuss different mechanisms whereby macrophages could directly influence the surviva...

Methamphetamine (METH) is a widely abused illegal psychostimulant, which is confirmed to be neurotoxic and of great damage to human. Studies on the role of brain-derived neurotrophic factor (BDNF) in human METH addicts are limited and inconsistent. The purposes of this study are to compare the serum BDNF levels between METH addicts and healthy controls during early withdrawal, and explore the c...