Background and Aims : It is now well established that non-alcoholic fatty liver disease (NAFLD) associated with a significant increase in the risk of adverse cardiovascular events. NAFLD-specific scores, considering traditional nontraditional factors, are needed to improve patient care. Liver fibrosis may be an integrative indicator burden cardiometabolic factors. also represent subclinical ath...

UNLABELLED Serum ferritin (SF) levels are commonly elevated in patients with nonalcoholic fatty liver disease (NAFLD) because of systemic inflammation, increased iron stores, or both. The aim of this study was to examine the relationship between elevated SF and NAFLD severity. Demographic, clinical, histologic, laboratory, and anthropometric data were analyzed in 628 adult patients with NAFLD (...

BACKGROUND While non-alcoholic fatty liver disease (NAFLD) has been well characterised in patients with diabetes mellitus (DM), less is known about NAFLD in non-DM patients. We investigated the clinical characteristics of NAFLD patients with and without DM and accuracy of the NAFLD fibrosis score (NFS) in these two NAFLD groups. METHODS Clinical, biochemical and histological variables were ev...

当院で2018年7月から2019年6月にかけて腹部CTまたは腹部超音波検査で脂肪肝を認めた非飲酒症例85例を対象にTransient Elastographyを施行し，食事摂取状況を調査した．単変量解析で，FAST score高値群はビタミンEや一価不飽和脂肪酸，多価不飽和脂肪酸の摂取が有意に少なく，多変量解析では高齢と多価不飽和脂肪酸の低摂取が独立因子として抽出された．FAST score高値症例の栄養指導時には多価不飽和脂肪酸の摂取を推奨する必要があることが示唆された．

BACKGROUND/AIMS The aims of this study were (1) to identify the useful clinical parameters of noninvasive approach for distinguishing nonalcoholic steatohepatitis (NASH) from nonalcoholic fatty liver disease (NAFLD), and (2) to determine whether the levels of the identified parameters are correlated with the severity of liver injury in patients with NASH. METHODS One hundred and eight consecu...

Nonalcoholic fatty liver disease (NAFLD), a metabolic disorder related to insulin resistance and metabolic syndrome, has become a public health concern. Currently, the principal therapeutic modalities targeting NAFLD are lifestyle interventions. However, the efficacy of long-term lifestyle interventions in managing NAFLD remains largely unexplored. This study aimed to evaluate the efficacy of l...

This study evaluated the effect of weight loss on pediatric nonalcoholic fatty liver disease (NAFLD). Subjects included 81 overweight NAFLD patients referred to two pediatric gastroenterologists from 2000 to 2010. Data on subjects were obtained from review of medical charts. The effect of weight loss was assessed at 1-4 months, 5-8 months, 9-12 months, and beyond one year as the change in weigh...

BACKGROUND We investigated the association between the severity of non-alcoholic fatty liver disease (NAFLD) and the estimated 10-year risk of cardiovascular disease (CVD) calculated by Pooled Cohort Equation (PCE) and Framingham risk score (FRS). METHODS A total of 15,913 participants (mean age, 46.3 years) in a health screening program were selected for analysis. The presence and severity o...

UNLABELLED Non-alcoholic fatty liver disease (NAFLD) has been proposed as the hepatic manifestation of the metabolic syndrom (Ms), with insulin resistance (IR) as the common pathophysiological mechanism. METHODS We included 145 patients with NAFLD proven liver biopsy. NAS-score was employed to grading NAFLD. We determined anthropometric measurements, basal blood pression (BP), biochemical mea...