PURPOSE OF REVIEW This article will enable the reader to diagnose and treat nervous system Lyme disease appropriately. RECENT FINDINGS Appropriately applied serologic testing has high positive and negative predictive values in nervous system Lyme disease. Oral antibiotics can be curative in most cases. SUMMARY Infection with the tick-transmitted spirochete Borrelia burgdorferi causes Lyme d...

Risk of multisystem disease in isolated ocular angioma (haemangioblastoma) EDITOR—Ocular angioma (haemangioblastoma) is the most common presenting feature of the multisystem famil-ial cancer syndrome von Hippel-Lindau disease (VHL). 1 Recognition of VHL is important because of the opportunity to reduce morbidity and mortality by early diagnosis of renal cell carcinoma, phaeochromocytoma, and ce...

Clinical stratification and response evaluation The ignorance of the pathogenesis and the failure to establish generally accepted diagnostic criteria have inhibited the development of a rational treatment policy for multisystem LCH. The therapy for LCH, therefore, has varied over the past century according to what was believed to be the cause of the disease. Only with the introduction of new co...

Major depressive disorder (MDD) has been associated with reduced leukocyte telomere length (LTL). It is not known, however, whether psychosocial and behavioral protective factors moderate this association. In the current study, we examine whether multisystem resiliency--defined by healthy emotion regulation, strong social connections, and health behaviors (sleep and exercise)--predicts LTL and ...

Lyme disease is a tick-transmitted multisystem inflammatory disease caused by the spirochete Borrelia burgdorferi. With more than 25,000 CDC reported cases annually, it has become the most common vector-borne disease in the United States. We report a case of 38-year-old man with Lyme disease presenting with simultaneous palsy of 3rd, 5th, 7th, 9th, and 10th cranial nerves.

OBJECTIVE: To review the literature on the hypoxic-ischemic syndrome, emphasizing its physiopathology, clinical manifestations, and treatment. SOURCES: Electronic search in the Medline and LILACS databases, with selection of the most relevant articles. SUMMARY OF THE FINDINGS: The hypoxic-ischemic syndrome is a multisystem disease with generalized manifestations. The physiopathology is based on...

Langerhans cell histiocytosis (LCH) is a rare histiocytic neoplasm. The clinical presentation and the disease extension are variable. LCH may involve single site, multiple sites within system, or systems. Gastrointestinal tract involvement most often observed in children with multisystem disease. Adult patients gastrointestinal extremely rare, only few cases have been reported. We present 45-ye...

T HE CLINICAL EFFECTS of erythrocyte enzymopathies vary widely in humans. In some, such as glyoxalase II deficiency,’ there are no apparent clinical mani festations, hematologic or otherwise. The ability to convert methylglyoxal to lactate, therefore, may have little or no role in human metabolism. In other enzymopathies, there are no hematologic manifestations, but the red cell shares an abnor...

BACKGROUND Neonatal-onset multisystem inflammatory disease is characterized by fever, urticarial rash, aseptic meningitis, deforming arthropathy, hearing loss, and mental retardation. Many patients have mutations in the cold-induced autoinflammatory syndrome 1 (CIAS1) gene, encoding cryopyrin, a protein that regulates inflammation. METHODS We selected 18 patients with neonatal-onset multisyst...