Severe Acute Respiratory Coronavirus-2 [SARS-CoV-2] emerged as a great threat to the world at end of December 2019 in China. The SARS-CoV-2 evolved from virus responsible for SARS epidemic 2002. has high rate human-human transmission and originated bat. It close resemblance with bat-like-SARS-CoV compared SARS-CoV; however, Spike protein virus-host cell interaction possesses least similarity th...

Surgical resections are considered the standardized therapy for primary cancers of the liver and for the majority of the metastatic disease affecting this organ [1,2]. Outcome of hepatic resections is influenced primarily by massive bleeding during resection and the subsequent need for blood transfusion [3,4]. The standard technique to control intraoperative bleeding is The Pringle maneuver [5]...

Multiple organ dysfunction syndrome (MODS), defined as the presence of altered organ function in an acutely ill patient such that homeostasis cannot be maintained without intervention, is a cause of high morbidity and mortality in humans and animals. Many advances have been made in understanding the pathophysiology and treatment of this syndrome in human medicine, but much still is unknown. Thi...

Urinary trypsin inhibitor (UTI), a serine protease inhibitor, has been widely used in Japan as a drug for patients with acute inflammatory disorders such as disseminated intravascular coagulation (DIC), shock, and pancreatitis. Recent in vitro studies have demonstrated that serine protease inhibitors may have anti-inflammatory properties beyond their inhibition of neutrophil elastase at the sit...

A 50 years old male patient to referred to our clinic for multiple hard diffused lesions on palms, plantars and penis. The Genesis of the problem goes back to 10 years earlier. The lesions appeared first on the soles and gradually new lesions appeared on the palms and eventually on the penis, so that stretching and contraction of the fingers and toes has become painful. During the last 6 years,...