PURPOSE To compare intravitreal bevacizumab monotherapy with intravitreal dexamethasone delayed delivery system monotherapy for persistent diabetic macular edema. METHODS Single-center, randomized, subject-masked study of eyes with persistent diabetic macular edema, defined as central subfield thickness (CST) >340 μm despite ≥3 anti-vascular endothelial growth factors injections within 5 mont...

BACKGROUND AND PURPOSE Zonisamide (ZNS) is a useful antiepileptic drug with a broad therapeutic spectrum. However, there is limited information on the long-term use of ZNS as a monotherapy. This study investigated the long-term effects of ZNS as a monotherapy for the treatment of epilepsy. METHODS We retrospectively analyzed the records of epilepsy patients treated with ZNS monotherapy at our...

conclusions these findings indicate that telbivudine, used in both monotherapy and combination therapy, improves the renal function of patients with chb. the improvements are particularly significant in patients at high renal risk. patients and methods this study included 336 chinese chb patients, who were selected from outpatients in tongji hospital. 44, 122, 66, 58, and 46 of these patients h...

Is there a place for monotherapy? Yes, there is a place for monotherapy. According to the Seventh report of the Joint National Committee in 2003 (1) and the European guidelines from 2007 (2) and 2009 (3), the first step in hypertension control is changing lifestyle before initiating medical treatment. According to the baseline blood pressure and the presence or absence of target organ damage an...

BACKGROUND The empirical treatment of febrile, neutropenic patients with cancer requires antibacterial regimens active against both gram-positive and gram-negative pathogens. This study was performed to demonstrate the noninferiority of monotherapy with piperacillin-tazobactam, compared with cefepime. METHODS We conducted a randomized-controlled, open-label, multicenter clinical trial among h...

BACKGROUND To determine the cost-effectiveness of strategies of preferred antibiotic treatment with beta-lactam/macrolide combination or fluoroquinolone monotherapy compared to beta-lactam monotherapy. METHODS Costs and effects were estimated using data from a cluster-randomized cross-over trial of antibiotic treatment strategies, primarily from the reduced third payer perspective (i.e. hospi...

Myelodysplasia (MDS) and secondary acute myeloid leukemia (sAML) are well-recognized complications of therapy with alkylating agents and topoisomerase II inhibitors. A recent comprehensive review of reported MDS/sAML rates concluded that up to 10% of patients treated for non-Hodgkin’s lymphoma (NHL) using either conventional dose alkylator-based regimens or high-dose therapy develop MDS or sAML...

PURPOSE To test the efficacy of selective therapy against cyclooxygenase-2 in combination with a low-dose regimen of a cytotoxic agent in the treatment of juvenile hematopoietic malignancies in the experimental model, Friend disease. EXPERIMENTAL DESIGN Juvenile erythroleukemic mice (n = 8) received no treatment, celecoxib (1600 mg/kg/d), vinblastine (0.5 microg/g twice weekly), vehicle contr...

Hematopoietic stem/progenitor cells (HSPCs) which give rise to different blood cell types are present within the bone marrow microenvironment, especially in flat bones such as skull, vertebrae, pelvis and chest. Interacting factors such as stromal derived factor-1/CXCR4, very late antigen-4/vascular cell adhesion molecule-1, Lymphocyte function-associated antigen-1/ intercellular adhesion molec...

Background The aim of this study was the ex vivo expansion of Umbilical Cord Blood hematopoietic stem cells on biocompatible nanofiber scaffolds. Materials and Methods CD133+ hematopoietic stem cells were separated from umbilical cord blood using MidiMacs (positive selection) system by means of monocolonal antibody CD133 (microbeads) subsequently, flowcytometry method was done to asses...