The molybdenum cofactor (Moco), a highly conserved pterin compound coordinating molybdenum (Mo), is required for the activity of all Mo-dependent enzymes with the exception of nitrogenase. Moco is synthesized by a unique and evolutionary old multi-step pathway with two intermediates identified so far, the sulfur-free and metal-free pterin derivative precursor Z and molybdopterin, a pterin with ...

Background Breath-hold (BH) segmented TURBO FLASH (TFL) is currently used as the gold standard technique to evaluate delayed enhancement (DE) of the myocardium, typically with a phase sensitive inversion recovery (PSIR) approach (1). However, many patients are unable to perform adequate breath-holding resulting in poor image quality and limited diagnostic yield. Free breathing (FB) single shot ...

The trace element molybdenum (Mo) is utilized in many life forms, and it is a key component of several enzymes involved in nitrogen, sulfur, and carbon metabolism. With the exception of nitrogenase, Mo is bound in proteins to a pterin, thus forming the molybdenum cofactor (Moco) at the catalytic sites of molybdoenzymes. Although a number of molybdoenzymes are well characterized structurally and...

Several ferrocenylalkynes have been prepared and their reaction with dicobalt octacarbonyl led to the formation of [Co2(CO)6(μ-η 2 : η-ethynylferrocene)] 1, [Co2(CO)6(μ-η 2 : η-1,4-bis(ferrocenyl)butadiyne)] 2, [(Co2(CO)6)2(μ-η : η,μ-η : η-1,4-bis(ferrocenyl)butadiyne)] 3, [Co2(CO)6(μ-η 2 : η-1-ferrocenylethynyl-2-hydro-1,2-dihydro[60]fullerene)] 4, [Co2(CO)6(μ-η 2 : η-1,1’-bis(phenylethynyl)fe...

A multiobjective combinatorial optimization (MOCO) formulation for the following location-routing problem in healthcare management is given: For a mobile healthcare facility, a closed tour with stops selected from a given set of population nodes has to be found. Tours are evaluated according to three criteria: (i) an economic efficiency criterion related to the tour length, (ii) the criterion o...

Amorphous ultrathin MoCo x O y nanosheets with excellent OER catalytic performance were prepared, and the incorporation of molybdenum to enable a lattice oxygen oxidation mechanism (LOM).

We have previously developed an adaptation of the simulated annealing for multi-objective combinatorial optimization (MOCO) problems to construct an approximation of the e$cient set of such problem. In order to deal with large-scale problems, we transform this approach to propose an interactive procedure. The method is tested on the multi-objective knapsack problem and the multi-objective assig...

To understand low temperature and osmotic stress signaling in plants, we isolated and characterized two allelic Arabidopsis mutants, los5-1 and los5-2, which are impaired in gene induction by cold and osmotic stresses. Expression of RD29A-LUC (the firefly luciferase reporter gene under the control of the stress-responsive RD29A promoter) in response to cold and salt/drought is reduced in the lo...

Human sulfite oxidase (hSO) was immobilised on SAM-coated silver electrodes under preservation of the native heme pocket structure of the cytochrome b5 (Cyt b5) domain and the functionality of the enzyme. The redox properties and catalytic activity of the entire enzyme were studied by surface enhanced resonance Raman (SERR) spectroscopy and cyclic voltammetry (CV) and compared to the isolated h...

Human molybdenum-containing enzyme mitochondrial amidoxime reducing component (mARC), cytochrome b5 type B, and NADH cytochrome b5 reductase form an N-reductive enzyme system that is capable of reducing N-hydroxylated compounds. Genetic variations are known, but their functional relevance is unclear. Our study aimed to investigate the incidence of nonsynonymous single nucleotide polymorphisms (...