The aim of the present study was to explore the levels of matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the maternal umbilical serum, placenta and decidua of patients with preeclampsia compared with those in normotensive pregnant females. A total of 73 pregnant females were recruited as the test subjects, including 43 inpatients with hypertensive dis...

Serial measurements of the plasma concentration of fibrinopeptide A, thrombin-increasable fibrinopeptide B (reflecting B beta 1-42), desarginyl fibrinopeptide B, beta thromboglobulin, and platelet factor 4 were made before, during, and after delivery in patients with preeclampsia/eclampsia. The data were correlated with routine coagulation studies, hematologic and renal status, as well as with ...

OBJECTIVE Paraoxonase is a high density lipoprotein-associated anti-oxidant enzyme. The aim of this study was to investigate the serum paraoxonase and arylesterase activities and associations between these enzymes and lipid hydroperoxide (LOOH) in preeclamptic patients. MATERIALS AND METHODS The study included 47 preeclamptic (25 severe and 22 mild preeclampsia cases) and 20 normotensive heal...

OBJECTIVE To estimate whether magnesium therapy is the optimal management for women with mild preeclampsia. METHODS A decision analytic model was designed for women with mild preeclampsia to estimate whether empiric magnesium therapy or no magnesium therapy is the optimal management strategy. The model considered relevant clinical events: seizure, placental abruption, and magnesium toxicity. ...

PROBLEM Published reports testing the association between cytokine levels and preeclampsia are conflicting. This comprehensive systematic review and meta-analysis aimed at testing the association between preeclampsia and maternal circulating tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, and IL-10. METHOD OF STUDY A systematic literature search of studies reporting maternal circulat...

Background: Measurements of optic nerve sheath diameter (ONSD) in intracranial pathologies correlate well with raised ICP. Only recently the usefulness ocular ultrasonography preeclampsia has been sought. Objective current study was measurement ONSD and compare it to healthy pregnant females.Methods: A total 90 subjects were included divided into Group I- normal pregnancy (N=30), II - mild III-...

OBJECTIVE To determine whether women receiving 12-hour and 24-hour postpartum magnesium sulfate (MgSO4) therapy for mild preeclampsia have differing clinical courses. METHODS Consenting women with suspected mild preeclampsia were randomly assigned to 12 hours or 24 hours of MgSO4 postpartum therapy. Treatment was continued after the assigned time period if there was evidence of severe preecla...

Introduction: Inflammatory mediators could be laboratory markers of preeclampsia, as the induction an inflammatory process within placenta may trigger expression cancer antigen 125(CA125), C-reactive protein (CRP) and uric acid (UA). Regarding pathophysiology pre-eclampsia, there is defective trophoblastic invasion uteroplacental blood vessels that leads to placental ischemia, placenta.
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Introduction. Preeclampsia (PE) is an important cause of mortality and morbidity for mothers, fetuses, and the newborns. Placenta plays a pivotal role in pathogenesis of PE. Hepatic growth factor (HGF) is a cytokine expressed by the mesenchymal stalk of placental villi during pregnancy and assumes a paracrine role in trophoblasts which express its receptor (c-MET). In the present study, we inve...

Cigarette smoking adversely affects every organ system. Paradoxically, smoking during pregnancy has been associated with a reduced risk of preeclampsia. We reviewed previous epidemiologic and clinical studies on the association between smoking and preeclampsia from 1959 to March, 2006. A total of 48 epidemiologic studies were identified. Overall, smoking during pregnancy reduces the risk of pre...