BACKGROUND Our aim was to observe ultrasound-induced intravascular microbubble destruction in vivo and to characterize any resultant bioeffects. METHODS AND RESULTS Intravital microscopy was used to visualize the spinotrapezius muscle in 15 rats during ultrasound delivery. Microbubble destruction during ultrasound exposure caused rupture of < or = 7-microm microvessels (mostly capillaries) an...

INTRODUCTION Gas-filled microbubbles were originally developed as an intravascular contrast agent to enhance backscattering in ultrasound imaging. Microbubbles possess the ability to be an MR susceptibility contrast agent due to the induction of large local magnetic susceptibility differences by the gas-liquid interface. Feasibility of microbubbles as an MR pressure sensor, based on the suscept...

Microbubble generators are in wide demand industry following the discovery of a number new functions microbubble mixtures. This paper deals with Venturi tube generator which air bubbles at inlet fragmented diverging part tube. In contrast past studies, we here regulated flow subsonic so that fragmentation occurred without help pressure shock waves. Counting microbubbles image processing, found ...

BACKGROUND Ultrasound can cause microbubble destruction. If microbubbles are administered as a continuous infusion, then their destruction within the myocardium and measurement of their myocardial reappearance rate at steady state will provide a measure of mean myocardial microbubble velocity. Conversely, measurement of their myocardial concentration at steady state will provide an assessment o...

Several emerging therapies with potential for use in the brain, harness effects produced by acoustic cavitation--the interaction between ultrasound and microbubbles either generated during sonication or introduced into the vasculature. Systems developed for transcranial MRI-guided focused ultrasound (MRgFUS) thermal ablation can enable their clinical translation, but methods for real-time monit...

We present the first all-Parylene microbubble pressure transducer (μBPT). The μBPT utilizes an electrolytically generated microbubble (μB), trapped in a Parylene microchamber, for pressure sensing. Pressure-induced bubble size variation is detected by electrochemical impedance measurement. Real-time hydrostatic pressure measurement with excellent sensitivity (-10.7 Ω/psi, ±0.1 psi) up to 1.8 ps...

1. Agarwal A., Ng W.J., and Liu Y., 2011. Principle applications of microbubble nanobubble technology for water treatment. Chemosphere, 84, 1175-1180. https://doi.org/10.1016/j.chem.... CrossRef Google Scholar

We showed previously that microbubble destruction with pulsed 1-MHz ultrasound creates a bioeffect that stimulates arteriogenesis and a chronic increase in hyperemia blood flow in normal rat muscle. Here we tested whether ultrasonic microbubble destruction can be used to create a microvascular remodeling response that restores hyperemia blood flow to rat skeletal muscle affected by arterial occ...

BACKGROUND AND PURPOSE Cerebral perfusion imaging in acute stroke assists in determining the subtype and the severity of ischemia. Recent studies in perfusion models and in healthy volunteers have shown that ultrasound perfusion imaging based on microbubble destruction can be used to assess tissue perfusion. We applied ultrasound microbubble destruction imaging (MDI) to identify perfusion defic...