Background: Trace elements play an important role in a number of biological processes. Astaxanthin (ASX), a carotoid pigment found in certain marine plant and animals, has shown anti cancer and anti free radical properties. This work intended to understand the effect of Astaxanthin in breast cancer (invasive ductal carcinoma, IDC) by using micro-pixe method. For this aim the concentratio...

Abstract Liver disease has become a major comorbidity health concern in people living with HIV-1 (PLWH) receiving antiretroviral therapy (ART). To investigate the immune mechanism of liver development ART-treated HIV-infected individuals, we developed humanized mice, NRG mice reconstituted progenitor cells from human fetal livers, infection and ART. Animals w/o were treated TRUVADA (Emtricitabi...

Objective(s): Liver transplantation is the most important therapy for end-stage liver disease and ischemia reperfusion (I/R) injury is indeed a risk factor for hepatic failure after grafting. The role of miRNAs in I/R is not completely understood. The aim of this study was to investigate the potential protective role of the mesenchymal stem cells (MSCs) and ischemic pr...

abstract       background and objectives: antibiotic resistance in bacteria has actuated researchers toward evaluating many new antibacterial compounds of which are the thiazoles. in this research the inhibitory effects of novel thiazole derivatives were unraveled on staphylococcus aureus, streptococcus agalactiae, pseudomonas aeruginosa and klebsiella pneumoniae and oxothiazole liver toxicity ...

Abstract No highly efficacious anti-malaria vaccine exists, but whole parasite immunization (WPI)where hosts receive live attenuated Plasmodium parasites that arrest in the liver is only strategy confers complete protection against future infection. Liver-resident memory CD8 T cells (TRM)that express chemokine receptor, CXCR3, are essential for WPI-induced protection. Yet, whether CXCR3-depende...

Effect of Concomitant Use Curcumin during Six Weeks Aerobic Exercise on Antioxidant Indices Liver Tissue in Mice with Induced Breast Cancer the Doxorubicin Treatment Phase

objective: acetaminophen (apap) overdose causes acute liver injuries. studies show that stem cell factor (scf) and its receptor, c-kit, enhance liver recovery from apap-induced injuries in mice. in this study we explore the effect of scf on activity of glutathione s-transferase (gsts) enzymes which are considered to be important in apap metabolism. methods: we divided 45 balb/c mice into three...

Introduction Dendritic cells (DCs) are bone marrow-derived cells, which migrate to lymphoid and non-lymphoid organs via blood. Liver DCs are believed to play an important role in the regulation of hepatic allograft acceptance. However, because of inherent difficulties in isolating adequate numbers of DCs from liver, limited information is available on the phenotype and functions of liver DCs. ...