Vascular smooth muscle cells (VSMCs) have been widely recognized as key players in regulating blood-brain barrier (BBB) function, their roles are unclear ischemic stroke. Myosin phosphatase target subunit 1 (MYPT1) is essential for VSMCs contraction and contributes to maintaining healthy vasculature. We generated VSMC-specific MYPT1 knockout mice (MYPT1SMKO mice) cultured infected with Lv-shMYP...

Itch is a typical symptom that exacerbates atopic dermatitis (AD) and associated with both the central peripheral nervous systems. In previous study, pruritogen mediators (histamine, serotonin, substance P, interleukin 31, thymic stromal lymphopoietin) secreted in skin bind to their receptors located on somatosensory neurons transmit itch signals brain. this we aimed elucidate profile of dorsal...

Abstract Heat stress has multiple potential effects on the brain, such as neuroinflammation, neurogenesis defects, and cognitive impairment. β-hydroxybutyric acid (BHBA) been demonstrated to play neuroprotective roles in various models of neurological diseases. In present study, we investigated efficacy BHBA alleviating heat stress-induced impairments adult hippocampal function, well underlying...

Human cysticercosis is a disease caused by larvae of the cestode Taenia solium. It an important common cause adult-onset seizures world-wide where it exacts debilitating toll on health and well-being affected communities. commonly assumed that major symptoms associated with are result direct presence in brain. As result, possible effects peripherally located central nervous system not well unde...

Abstract Following a traumatic brain injury (TBI), excess reactive oxygen species (ROS) and lipid peroxidation products (LPOx) are generated lead to secondary beyond the primary insult. A major limitation of current treatments is poor target engagement, which has prevented success in clinical trials. Thus, nanoparticle‐based have received recent attention because their ability increase accumula...

Abstract Background DHA‐H (2‐hydroxy‐docosahexaenoic acid) is a promising therapeutic approach for Alzheimer’s Disease (AD). gives rise to dose‐dependent increased levels of HPA (Heneicosapentaenoic in blood plasma and brain whereas remains virtually absent from the DHA‐H‐treated mice. Oral administration transgenic model AD (5xFAD mice) induces significative cognitive recovery. However, molecu...

To investigate the effects of the two-pore-domain potassium (K2P) channel TASK-3 in a syngeneic murine model for malignant glioma. Malignant or high-grade glioma (WHO grade III and IV) are the most common and most aggressive primary brain tumors in adults. Despite aggressive multimodal therapy, the outcome of patients with malignant glioma remains poor. However, recent phase I and II trials hav...

Background Brain pericytes maintain the integrity of blood-brain barrier (BBB) and facilitate removal amyloid β (Aβ) which is critical to healthy brain activity (Ethan et al., Pathol., 24: 371-386, 2014). Pericyte degeneration has been observed in brains from patients with Alzheimer’s disease (AD) animal models (Jesse 23: 303-10, 2013; Wu Aging (Albany NY), 11: 6120-6133, 2019). Our previous da...

Background and Aim: In this study, we investigated the effect of immobilization stress during pregnancy on the spatial memory, anxiety-like behavior and brain BDNF level in F1 generation male NMRI mice. Materials and Methods: Twenty female pregnant mice were randomly divided into stress and control groups. The stress group received stress using a restraint cylinder (6 cm ID, 20 cm L) 60 min/da...