INTRODUCTION Methanol poisoning continues to be a serious public health issue in Taiwan, but very little work has been done to study the outcomes of methanol toxicity in the Asian population. In this study, we examined the value of multiple clinical variables in predicting mortality after methanol exposure. METHODS We performed a retrospective observational study on patients with acute poison...

Methanol is responsible for a life-threatening poisoning. Fomepizole, a potent alcohol dehydrogenase inhibitor, is an efficient and safe antidote that prevents or reduces toxic methanol metabolism. Although no study has compared its efficacy with ethanol, fomepizole is recommended as a first-line antidote. Treatment should be started as soon as possible, based on history and initial findings in...

OBJECTIVES To present the visual sequelae of methanol poisoning and to emphasize the characteristics of methanol exposure in the Kingdom of Saudi Arabia (KSA). METHODS A retrospective case series was carried out on 50 sequential patients with methanol poisoning seen at the King Khaled Eye Specialist Hospital and King Saud University Hospitals in Riyadh, KSA between 2008 and 2014. All patients...

Background. Alcohol variants such as ethanol and methanol are simple organic compounds widely used in foods, pharmaceuticals, chemical synthesis, etc. Both are becoming an emerging health problem; abuse of ethanol containing beverages can lead to disparate health problems and methanol is highly toxic and unfit for consumption. Methods and Results. This review summarizes the basic knowledge abou...

The histopathologic effects of methanol on the optic nerve were studied in four patients. Circumscribed myelin damage occurred behind the lamina cribrosa in each nerve. Axons were preserved. Demyelination also occurred in cerebral hemispheric white matter in one patient. This selective myelinoclastic effect of methanol metabolism is probably caused by histotoxic anoxia in watershed areas of the...

BACKGROUND Methanol is a colorless and poisonous liquid that is commonly used as an industrial and household solvent. Methanol poisoning is a rare but extremely hazardous form of in toxication that affects the central nervous system and causes visual disorder, drowsiness, seizures and coma. CASE PRESENTATION A 29-years-old man with methanol intoxication presented with drowsiness and acidosis ...

In the previous letter, we reported a case of recurrent sniffing of toluene and methanol, and discussed the relationship between neuro-psychological symptoms and urinary findings1). As the patient has neither complained of visual disturbance nor been diagnosed with optic nerve alteration, which is well-known sequela of methanol poisoning, we were interested in the urinary excretion of methanol ...

A simple method was developed for determination of illudin S in fungi (Omphalotus guepiniformis: poisonous mushroom) and a food that caused food poisoning, using liquid chromatography tandem mass spectrometry (LC/MS/MS). Illudin S in fungi and the food that caused food poisoning was extracted with methanol and then cleaned up with an Oasis HLB cartridge. LC separation was performed with an octa...