OBJECTIVES To validate 99mTc-labeled arginylglycylaspartic acid (99mTc-3PRGD2) scintigraphy as a means to image synovial neoangiogenesis in joints afflicted by rheumatoid arthritis and to investigate its potential in the early detection and management of rheumatoid arthritis. METHODS Rheumatoid arthritis and osteoarthritis were generated in Sprague Dawley rats by type II collagen immunization...

Received 7/23/2005; revised 7/29/2005; accepted 8/3/2005. For correspondence or reprints contact: Yeh-You Shen, M.D., Division of Nuclear Medicine, Shin Kong Wu Ho-Su Memorial Hospital. 95 Wen Chang Road., Shih Lin District, Taipei 111, Taiwan. Tel: (886)2-28332211 ext. 2280, Fax: (886)2-28389489, E-mail: [email protected] A 52-year-old man with history of medullary thyroid cancer (MTC) rec...

body skeletal scintigraphy performed with 20 mCi (740 Mega Becquerel) of Technetium-99m Methylene DiphosPhonate (MDP) revealed diffusely increased tracer uptake over body of sternum and manubriosternal junction suggestive of neoplastic process. A focal area of benign uptake was also seen over left 2nd costochondral junction (Fig. 3). Contrast enhanced CT study revealed mixed sclerotic and lytic...

UNLABELLED We prospectively evaluated the use of combined (18)F-NaF/(18)F-FDG PET/CT in patients with breast and prostate cancer and compared the results with those for (99m)Tc-MDP bone scintigraphy and whole-body MRI. METHODS Thirty patients (15 women with breast cancer and 15 men with prostate cancer) referred for standard-of-care bone scintigraphy were prospectively enrolled in this study....

A 25-year-old patient with osteosarcoma of the right distal femur underwent a bone scintigraphy with Tc-99m methylene diphosphonate (MDP). Whole-body bone scan revealed extensive metastatic disease in the abdominal region. Abdominal computerized tomography confirmed the presence of ascites and calcified masses on the greater omentum and peritoneal surfaces. Here we describe a case of unusual me...

Markedly elevated111 In labeled leukocyte activity suggestive of acute osteomyelitis was observed in a region of a composite mandibular allograft that was photon deficient on 99mTc MDP bone scintigraphy. This finding was later confirmed by surgical pathology. The patient was treated with intravenous antibiotics and returned two months later with persistent bone infection. The foHow-up thr...

markedly elevated111 in labeled leukocyte activity suggestive of acute osteomyelitis was observed in a region of a composite mandibular allograft that was photon deficient on 99mtc mdp bone scintigraphy. this finding was later confirmed by surgical pathology. the patient was treated with intravenous antibiotics and returned two months later with persistent bone infection. the fohow-up three pha...