The active site and substrate-binding mode of MD-ACO1 (Malus domestica Borkh. 1-aminocyclopropane-1-carboxylate oxidase) have been determined using site-directed mutagenesis and comparative modelling methods. The MD-ACO1 protein folds into a compact jelly-roll motif comprised of eight a-helices, 12 b-strands and several long loops. The active site is well defined as a wide cleft near the C-term...

Mixed Poisson distributions are widely used for modeling claim counts when the portfolio is thought to be heterogeneous. The risk (or mixing) distribution then represents a measure of this heterogeneity. The aim of this paper is to use a variant of the Patilea and Rolin [15] smoothed version of the Simar [20] Non-Parametric Maximum Likelihood Estimator of the risk distribution in the mixed Pois...

A new HPTLC method has been developed for the identification and quantification of ursolic acid in apple peel extract. Ursolic acid can be easily estimated after derivatization with Liebermann TABLE 1: RECOVERY STUDY OF URSOLIC ACID FROM MALUS DOMESTICA PEEL Amount spotted (μg) Peak area (AU) Amount detected (μg) RSD (%) Accuracy (%) 0.91 4098.7 0.91 1.12 100.9 1.14 4677.5 1.13 1.48 99.6 1.36 5...

In this paper, we investigate the impact of the claim reporting strategy of drivers, within a bonus malus system. We exhibit the induced modification of the corresponding class level transition matrix and derive the optimal reporting strategy for rational drivers. The hunger for bonuses induces optimal thresholds under which, drivers do not claim their losses. A numerical algorithm is provided ...