We have demonstrated that 50-mum-diameter arteriovenous pathways exist in isolated, healthy human and baboon lungs, ventilated and perfused under physiological pressures. These findings have been confirmed and extended by demonstrating the passage of 25-microm microspheres through the lungs of exercising dogs, but not at rest. Determination of blood flow through these large-diameter intrapulmon...

A 65-year-old male presented with unexplained hypoxia that became exacerbated by an upright posture (platypnea-orthodeoxia syndrome) secondary to hepatopulmonary syndrome (HPS). A (99m)Tc-macroaggregated albumin pulmonary perfusion scan revealed a right to left shunt of 29% in the sitting position, which had not been previously detected when the radiotracer injection was performed with the pati...

c 5 XTRAPULMONARY accumulation of Tc macroaggregated albumin (MAA) is rarely een on perfusion lung scan, and has been reported n less than 4% of a study population of nearly 380 atients.1 It occurs when the agent bypasses the ungs due to a right-to-left (R-L) cardiac or pulonary shunt, when it is shunted to the portal vein efore reaching the right atrium and ventricle of he heart, and when the ...

This agent ( 2 ‘,,‘/mi) disrupts microfilaments in many cell types including the AM.2 It does not impair microtubular morphology. Quantitative bacteriologic methods demonstrate diminished uptake of live Staphylococcus aureus from shaking bacteriaAM suspensions in the presence of cytochalasin B. These effects are associated with striking diminution of ‘4C02 production from ‘4C-1-glucose and ‘4C-...

Rapid developments in the field of medical imaging have opened new avenues for the use of positron emitting labeled microparticles. The radioisotope used in our research was (68)Ga, which is easy to obtain from a generator and has good nuclear properties for PET imaging. Methods. Commercially available macroaggregated albumin (MAA) microparticles were suspended in sterile saline, centrifuged to...