Prilocaine-induced methemoglobinemia is a rarely seen condition. In this paper, a case is presented with methemoglobinemia developed secondary to prilocaine use in a liposuction procedure, and the importance of this rarely seen condition is emphasized. A 20-year-old female patient presented with complaints of prostration, lassitude, shivering, shortness of breath, and cyanosis. It was learned t...

every month, after a period of prodromes consisting of headache and general lassitude, a flow of clear non-coagulable blood took place from the right ear, in which no pre-existing local lesion could be determined. After three years the ordinary genital discharge began to take place, gradually replacing that from the ear, which only occurred every two or three months. The author remarks that the...

Chronic mountain sickness (CMS) represents a variably reversible asynchronous syndrome of secondary polycythemia along with erythrocytosis, erythrocyte aggregation, hemoglobinemia, hemoconcentration, thrombocytopenia, increased whole blood viscosity, fibrinogenemia, prothrombotic state, pulmonary and systemic hypertension, and congestive heart failure, occurring due to hypobaric hypoxia-anoxia-...

BACKGROUND Acute Mountain Sickness (AMS) is a multi-system disorder that is characterized by headache, anorexia, nausea, vomiting, insomnia, lassitude, and malaise. The syndrome is common in unacclimatized low altitude residents who rapidly ascend to terrestrial elevations exceeding 2,500 m. AMS may be a manifestation of hypoxia-induced cerebral edema resulting, in part, from increased capillar...

OBJECTIVE To describe the frequency of reported sleeping, depression and pain problems, the severity of these problems and the degree of self-estimated difficulties in mental functions and activities in relation to the sleep disturbance and pain category group in patients on long-term sick-leave. DESIGN Cross-sectional study. PATIENTS A total of 1206 patients experiencing difficulty in resu...

Fatigue is a very common symptom of multiple sclerosis (MS). Theoretically, fatigue may be related to neuromodulation by soluble products of the autoimmune process or by disruption of central nervous system pathways necessary for sustained activity, but little empirical evidence supports these possibilities. Amantadine, pemoline, and modafanil improved fatigue in placebo-controlled clinical tri...

Statistics report a three to four times increased likelihood of developing a depressive episode in individuals afflicted with systemic inflammation (1), showing higher levels of inflammatory markers such as C-reactive protein (CRP) or interleukin-6 (IL-6) in patients with major depressive disorder (MDD) (2). However, the molecular mechanisms underlying this relationship remain to be further inv...

BACKGROUND Few studies have compared the psychopathology of patients with seasonal and nonseasonal mood disorders. METHOD We compared the psychopathology of a consecutively referred sample of seasonal affective disorder (SAD) outpatients (N = 87) with that of hospitalized suicide attempters who had nonseasonal major depression (N = 65) by using the Comprehensive Psychopathological Rating Scal...

I NSULIN is essential for the normal metabolism of carbohydrates, lipids and proteins in the monogastric animal (Tepperman, 1968) ; however, its role in the normal metabolism of ruminants is poorly understood. Since alloxan-induced diabetes produced a similar response in ruminant and nonruminant animals (Reid, Hinks and Mills, 1963; Jarret, 1946) and depancreatized sheep behaved similarly to al...

BACKGROUND The advent of global clinical trials has necessitated the use of English-based rating instruments in diverse cultures where English is clearly not the primary language. The cross-cultural applicability of rating instruments developed in one language with only one cultural group is an important issue in both research and clinical settings where these instruments might be used. We exam...