نتایج جستجو برای: lactamase enzymes

تعداد نتایج: 137918  

Journal: :The Journal of antimicrobial chemotherapy 2014
Krisztina M Papp-Wallace Susana Mallo Christopher R Bethel Magdalena A Taracila Andrea M Hujer Ana Fernández Julian A Gatta Kerri M Smith Yan Xu Malcolm G P Page Eric Desarbre Germán Bou Robert A Bonomo

OBJECTIVES Class C β-lactamases are prevalent among Enterobacteriaceae; however, these enzymes are resistant to inactivation by commercially available β-lactamase inhibitors. In order to find novel scaffolds to inhibit class C β-lactamases, the comparative efficacy of monocyclic β-lactam antibiotics (aztreonam and the siderophore monosulfactam BAL30072), the bridged monobactam β-lactamase inhib...

Journal: :Journal of biomolecular screening 2010
Gentaroh Suzuki Hiroshi Kawamoto Hisashi Ohta

mGluR1 antagonists have been postulated to be novel CNS drugs, including antipsychotics. Toward this end, the authors developed a beta-lactamase reporter assay to identify mGluR1 antagonists. beta-Lactamase has several interesting features for high-throughput screening, including very high sensitivity and less well-to-well variation than other reporter enzymes. mGluR1-expressing Chinese hamster...

Journal: :Journal of the American Chemical Society 2003
Samy O Meroueh George Minasov Wenlin Lee Brian K Shoichet Shahriar Mobashery

Penicillin-binding proteins (PBPs), biosynthetic enzymes of bacterial cell wall assembly, and beta-lactamases, resistance enzymes to beta-lactam antibiotics, are related to each other from an evolutionary point of view. Massova and Mobashery (Antimicrob. Agents Chemother. 1998, 42, 1-17) have proposed that for beta-lactamases to have become effective at their function as antibiotic resistance e...

2017
KO Akinyemi Bamidele Abiodun Iwalokun Akeeb O Bola Oyefolu CO Fakorede

PURPOSE Salmonella spp. are important foodborne pathogens exhibiting increasing resistance to antimicrobial drugs. Resistance to broad-spectrum β-lactams, mediated by extended-spectrum β-lactamase (ESBL) and AmpC β-lactamase enzymes is fast spreading and has had negative impacts on the clinical outcomes, particularly on third-generation cephalosporins. This study investigated the carriage of Am...

Journal: :Antimicrobial agents and chemotherapy 2003
Conor E Jamieson Peter A Lambert Iain N Simpson

AM-112 [(1'R,5R,6R)-3-(4-amino-1,1-dimethyl-butyl)-6-(1'-hydroxyethyl)oxapenem-3-carboxylate] is a novel oxapenem compound which possesses potent beta-lactamase-inhibitory properties. Fifty-percent inhibitory concentrations (IC(50)s) of AM-112 for class A enzymes were between 0.16 and 2.24 micro M for three enzymes, compared to IC(50)s of 0.008 to 0.12 micro M for clavulanic acid. Against class...

Journal: :Antimicrobial agents and chemotherapy 2000
J Fiett A Pałucha B Miaczyńska M Stankiewicz H Przondo-Mordarska W Hryniewicz M Gniadkowski

Twenty-two Klebsiella pneumoniae and two K. oxytoca extended-spectrum beta-lactamase (ESBL)-producing isolates were collected in 1996 from patients in two pediatric wards of the University Hospital in Wrocław, Poland. Molecular typing has revealed that the K. pneumoniae isolates represented four different epidemic strains. Three kinds of enzymes with ESBL activity (pI values of 5.7, 6.0, and 8....

Journal: :International Journal of Health Sciences (IJHS) 2022

The study included isolation and diagnosis of Escherichia coli from clinical animal sources (humans, cows, sheep, birds, chickens, fish, gecko). It collected 275 samples distributed to 125 taken urine 150 other organisms with 25 per organism. isolates used in the were diagnosed on appearance, microscopy, chemical tests, as well confirmatory testing isolations through use Api 20 E tape, where 41...

2008
Ritu Aggarwal Sanjeev Ahuja

AmpC β-lactamase enzymes confer resistance to a wide variety of β-lactam antibiotics, except carbapenems. AmpC β-lactamase-producing bacteria are known to be causative pathogens of nosocomial infections, which are difficult to be treated. Hence, this study was aimed out to determine the prevalence of AmpC β-lactamase enzyme production among Gram-negative bacteria. A total of 500 multidrug-resis...

Journal: :Antimicrobial agents and chemotherapy 2002
Sergei B Vakulenko Dasantila Golemi Bruce Geryk Maxim Suvorov James R Knox Shahriar Mobashery Stephen A Lerner

The class C beta-lactamase from Enterobacter cloacae P99 confers resistance to a wide range of broad-spectrum beta-lactams but not to the newer cephalosporin cefepime. Using PCR mutagenesis of the E. cloacae P99 ampC gene, we obtained a Leu-293-Pro mutant of the P99 beta-lactamase conferring a higher MIC of cefepime (MIC, 8 microg/ml, compared with 0.5 microg/ml conferred by the wild-type enzym...

2010
Sarah M. Drawz Robert A. Bonomo

INTRODUCTION .......................................................................................................................................................161 MECHANISM OF ACTION OF -LACTAM ANTIBIOTICS .............................................................................161 RESISTANCE TO -LACTAM ANTIBIOTICS ..........................................................................

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