Copper complexes of L-alanine, L-arginine, L-histidine, L-lysine, L-proline and L-threonine were studied for their antibacterial activity against Staphylococcus aureus, Streptococcus pyogenes and Escherichia Coli. The complexes of 1-alanine, 1-proline and 1-threonine were nearly as active as ampicillin against Strep. Pyogenes. Mixed complexes of these amino acids showed similar effect. Other co...

In order to elucidate whether or not the spectral and circular dichroic changes observed during the biodegradative threonine deaminase reaction are caused by the Schiff base formation between the enzyme-bound pyridoxal phosphate and the dehydrated intermediate, the role of substituents and the absolute configuration of the 0 carbon of substrates was investigated using various analogs of L-threo...

In order to elucidate whether or not the spectral and circular dichroic changes observed during the biodegradative threonine deaminase reaction are caused by the Schiff base formation between the enzyme-bound pyridoxal phosphate and the dehydrated intermediate, the role of substituents and the absolute configuration of the 0 carbon of substrates was investigated using various analogs of L-threo...

Threonine dehydratase converts L-threonine to 2-ketobutyrate. Several threonine dehydratases exist in bacteria, but their origins and evolutionary pathway are unknown. Here we analyzed all the available threonine dehydratases in bacteria and proposed an evolutionary pathway leading to the genes encoding three different threonine dehydratases CTD, BTD1 and BTD2. The ancestral threonine dehydrata...

In order to elucidate whether or not the spectral and circular dichroic changes observed during the biodegradative threonine deaminase reaction are caused by the Schiff base formation between the enzyme-bound pyridoxal phosphate and the dehydrated intermediate, the role of substituents and the absolute configuration of the 0 carbon of substrates was investigated using various analogs of L-threo...

Bacterial mechanisms for the uptake of peptides and their hydrolysis to amino acids are known in great detail, whereas much less is known about the fates of the peptide-derived amino acids. We show that the addition of L-threonine-containing di- or tripeptides results in reduction of the growth of Corynebacterium glutamicum, with concomitant high intracellular accumulation of L-threonine to up ...