Both LRF (Zbtb7a) and ThPOK (Zbtb7b) belong to the POK (BTB/POZ Kruppel) family of transcription repressors which participate in development, differentiation oncogenesis. While mediates osteoclast by regulating NFATc1 expression, principal established function is transcriptional control T-cell lineage commitment. Whether affects formation or function, not known.We find that marrow macrophage ex...

Chromosomal translocations involving band 3q27 are the recently described nonrandom cytogenetic abnormalities in B-cell malignancies. We have previously cloned the breakpoint region of 3q27, designated as the BCf5 locus, from the B-cell line carrying the t(3; 22). The cDNA for the BCf5 gene was cloned from the human liver cDNA library. The nucleotide sequencing analysis showed that the BCLB gen...

Цель работы состоит в развитии подхода к моделированию генных регуляторных сетей с учетом модульной структуры гена. Модель строится на основе экспериментальных данных и последующей экспериментальной верификации. Особенность подхода состоит в том, в модель включают дополнительные молекулярно-биологические детали, что более реалистично отражает механизмы контроля генной активности. Модельным объе...

Purpose: Coronary artery disease is defined as complications that develop in proportion to the prevalence of ischemia due occlusion coronary arteries and resulting cell death. The development atherosclerosis significantly influenced by endothelial dysfunction. Kruppel-like factor 2, a transcription factor, has been shown regulate critical biological events biology, such vascular tone, migration...

We constructed green fluorescent protein (GFP)-expressing balancer chromosomes for each of the three major chromosomes of Drosophila melanogaster. Expression of GFP in these chromosomes is driven indirectly by a Kruppel (Kr) promoter, via the yeast GAL4-UAS regulatory system. GFP fluorescence can be seen in embryos as early as the germ band extension stage, and can also be seen in larvae, pupae...