s Journal of the Peripheral Nervous System 5:169–188 (2000) 170 Alpha-lipoic acid (LPA) has marked effects in experimental diabetic neuropathy. Treatment for 2 weeks after 8 weeks of diabetes in rats corrected motor and sensory conduction velocity and endoneurial perfusion deficits with an ED 50 of approximately 40 mg/kg. There was no difference in efficacy between Rand S-enantiomers of LPA. Wh...