<p class="abstract">Juvenile dermatomyositis (JDM) is a rare autoimmune disease that affects mostly children's muscles and skin. The small number of patients with JDM, heterogeneous phenotype, few clinical trials for JDM pose challenges clinicians in developing standard treatment protocols. Although there has been some consensus, the obstacles to therapy, especially refractory cases, have...

Juvenile Dermatomyositis (JDM) is a systemic, inflammatory, idiopathic disease, mainly affecting the skin and the muscles, starting before the age of 16 with an incidence around one case per million children. Some patients display typical features of JDM without skin involvement or even without muscle involvement, however both tissues are affected over time in most cases. Diagnosis criteria hav...

OBJECTIVE To study muscle biopsies, using histochemistry, on ten children with infantile dermatomyositis. DESIGN Series of ten patients (of whom eight patients had received treatment and two had not) were submitted to muscle biopsy in order to diagnose possible inflammatory myopathy or to detect recurrences. PLACE OF DEVELOPMENT OF THE STUDY: Public Health Service of São Paulo State. PARTIC...

Methods/case 6 y/o girl from Kazakhstan presenting with discrete heliotrope of upper eyelids, erythema of the chest and extensor surfaces of extremities, Gottron’s papules as well as scarred piecemeal necrosis on 1 finger and 2 toes. Close examination revealed nailfold tortuositas. Muscle strength was 5/5, CMAS 48/51. Inflammatory parameters were not elevated, transaminases, CK and aldolase in ...